Assessment of antidiabetic, anti-inflammatory, antioxidant and anticancer activity competence of methonolic extracts of Trianthema ortulacastrum and Andrographis paniculata

• Published in: Environmental research 2024-02, Vol.242, p.117764-117764, Article 117764
• Main Authors: Wadaan, Mohammad Ahmad, Baabbad, Almohannad, Farooq Khan, Muhammad
• Format: Article
• Language: English
• Subjects: Andrographis - chemistry; Andrographis paniculata; Anti-inflammatory; Anti-Inflammatory Agents - pharmacology; Anticancer; Antidiabetic; Antioxidant; Antioxidants - pharmacology; Humans; Hypoglycemic Agents - pharmacology; Methanol - chemistry; Neoplasms; Plant Extracts - chemistry; Plant Extracts - pharmacology; Trianthema portulacastrum
• ISSN: 0013-9351; 1096-0953
• DOI: 10.1016/j.envres.2023.117764

An in-vitro investigation was performed to evaluate and compare the phytochemical, antioxidant, antidiabetic, anti-inflammatory, and anti-lung cancer activities of methanol extracts of aerial parts of Andrographis paniculata and Trianthema portulacastrum. Furthermore studied major functional groups of phytochemicals present in the methanol extracts of these plants through Fourier transform infrared (FTIR) analysis. The results showed that the methanol extract of A. paniculata contain more number of pharmaceutically valuable phytochemicals such as alkaloids, flavonoids, terpenoids, saponin, glycoside, phytosterol, and tannin than T. portulacastrum. Similar way the methanol extract of A. paniculata showed considerable dose dependent antioxidant (DPPH: 63%), antidiabetic (α-amylase: 82.31% and α-glucosidase inhibitions: 72.34%), and anti-inflammatory (albumin-denaturation inhibition: 76.3% and anti-lipoxygenase: 61.2%) activities (at 900 μg mL−1 concentration) than T. portulacastrum. However, the anti-lung cancer activities of these test plants against A549 cells were not considerable. According to FTIR analysis, the A. paniculata methanol extract has a larger number of characteristic peaks attributed to the active functional groups of pharmaceutically valuable bioactive components that belong to different types of phytochemicals. These findings imply that A. paniculata methanol extracts can be used for additional research, such as bioactive compound screening and purification, as well as assessing their potential biomedical uses in various in-vitro and in-research settings. •Andrographis paniculata methanol extract contain more valuable phytochemicals.•Dose dependent antioxidant, antidiabetic, and anti-inflammatory activities noted.•A. paniculata and T. portulacastrum methanol extract showed less anticancer activity.•Lung cancer cells A-549 cell lines used for in vitro study: MTT assay.•FTIR analysis proved methanol extract of A. paniculata more bioactive compounds.