A compartmental model for Schistosoma japonicum transmission dynamics in the Philippines

• Published in: Acta tropica 2024-01, Vol.249, p.107084-107084, Article 107084
• Main Authors: Kuo, Yuan-Jen, Paras, Gian, Tagami, Taiyo, Yi, Claire, Aquino, Leslie J Camacho, Oh, Hyunju, Rychtář, Jan, Taylor, Dewey
• Format: Article
• Language: English
• Subjects: Animals; Cattle; China - epidemiology; Elimination; Epidemiological Models; Humans; Mammals; Mechanization; Philippines - epidemiology; Schistosoma japonicum; Schistosomiasis; Schistosomiasis - epidemiology; Schistosomiasis japonica - parasitology; Snails - parasitology; Transmission dynamics
• ISSN: 0001-706X; 1873-6254
• DOI: 10.1016/j.actatropica.2023.107084

•Carabaos can sustain S. japonicum transmission.•Reducing bovine contact with water will result in reduction of human schistosomiasis prevalence.•Mechanization of agriculture can eliminate schistosomiasis in the Philippines. Schistosomiasis is a chronic and debilitating neglected tropical disease (NTD), second only to malaria as one of the most devastating parasitic diseases. Caused by a parasitic flatworm of the genus Schistosoma, infection occurs when skin comes in contact with contaminated freshwater that contains schistosome-hosting snails. The disease continues to be endemic in many regions of the Philippines, where it poses a significant public health challenge due to a lack of healthcare resources. In the Philippines, additional mammalian reservoirs for the S. japonicum parasite, especially bovines such as carabaos, also facilitate the spread of schistosomiasis. We extend existing compartment models to include human, snail, bovine, and free-living Schistosoma for a comprehensive look at the transmission dynamics of the disease. Sensitivity analysis of model parameters shows that the carabaos themselves can sustain the endemicity of schistosomiasis. Thus, we consider the control method of farming mechanization to avoid contaminated freshwater sources. We find that a reduction of contaminated water contacts by at least 77% will break the transmission cycle and eliminate the disease. However, reducing the contact by about 70% will still result in decrease of human schistosomiasis prevalence to under 1% in 15 years or less. Achieving such high reduction of contact rates could be a daunting task, especially in rural areas. Still, the potential to eliminate or at least reduce the schistosomiasis prevalence should be considered an additional benefit of mechanization efforts in the Philippines.