Metabolic Control of Cardiomyocyte Cell Cycle

Current therapies for heart failure aim to prevent the deleterious remodeling that occurs after MI injury, but currently no therapies are available to replace lost cardiomyocytes. Several organisms now being studied are capable of regenerating their myocardium by the proliferation of existing cardio...

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Bibliographic Details
Published in:Methodist DeBakey cardiovascular journal 2023, Vol.19 (5), p.26-36
Main Authors: Menendez-Montes, Ivan, Garry, Daniel J, Zhang, Jianyi Jay, Sadek, Hesham A
Format: Article
Language:English
Subjects:
Animals
Cell Cycle
Cell Proliferation
Heart Failure - metabolism
Heart Failure - therapy
Humans
Mammals
Myocardium - metabolism
Myocytes, Cardiac - metabolism
Regeneration - genetics
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Summary:Current therapies for heart failure aim to prevent the deleterious remodeling that occurs after MI injury, but currently no therapies are available to replace lost cardiomyocytes. Several organisms now being studied are capable of regenerating their myocardium by the proliferation of existing cardiomyocytes. In this review, we summarize the main metabolic pathways of the mammalian heart and how modulation of these metabolic pathways through genetic and pharmacological approaches influences cardiomyocyte proliferation and heart regeneration.
ISSN:1947-6108
1947-6108
DOI:10.14797/mdcvj.1309