Treatment of Cervical Precancers is the Major Remaining Challenge in Cervical Screening Research

Deepening understanding of cervical cancer pathogenesis has yielded one-dose prophylactic human papillomavirus (HPV) vaccines and accurate HPV-based cervical screening tests. Knowing the heterogeneous carcinogenic potential of the individual high-risk HPV types permits prioritization of vaccination...

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Bibliographic Details
Published in:Cancer prevention research (Philadelphia, Pa.) Pa.), 2023-12, Vol.16 (12), p.649-651
Main Authors: Desai, Kanan T, de Sanjosé, Silvia, Schiffman, Mark
Format: Article
Language:English
Subjects:
Cervix Uteri - pathology
Cervix Uteri - surgery
Early Detection of Cancer - methods
Female
Humans
Mass Screening
Papillomaviridae
Papillomavirus Infections
Papillomavirus Vaccines - therapeutic use
Uterine Cervical Dysplasia - diagnosis
Uterine Cervical Neoplasms - diagnosis
Uterine Cervical Neoplasms - pathology
Uterine Cervical Neoplasms - prevention & control
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Summary:Deepening understanding of cervical cancer pathogenesis has yielded one-dose prophylactic human papillomavirus (HPV) vaccines and accurate HPV-based cervical screening tests. Knowing the heterogeneous carcinogenic potential of the individual high-risk HPV types permits prioritization of vaccination and screening strategies. However, "correct" (i.e., safe and effective) treatment of women found to have precancer is still undefined, forcing reliance on one or more rounds of untargeted destructive/excisional treatment. Both over-treatment and under-treatment are common results. Until safe and effective anti-HPV therapies are invented, defining optimal destructive/excisional treatment of precancer remains a fundamental and under-researched challenge, especially in resource-constrained settings. See related article by King et al., p. 681.
ISSN:1940-6207
1940-6215
DOI:10.1158/1940-6207.CAPR-23-0448