Risk factors for prostate cancer in men with false-negative mpMRI: A retrospective single center cohort study of image quality scores and clinical parameters

•Analysis of missed PCa and csPCa in men with prior negative mpMRI.•Significance of MR image quality scores (PI-QUAL, PSHS) and clinical parameters.•Lower PI-QUAL score is an independent predictor of missed csPCa.•Integration of image quality scoring systems into standard prostate MRI reports. To id...

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Published in:European journal of radiology 2024-01, Vol.170, p.111227-111227, Article 111227
Main Authors: Pausch, Antonia M., Ghafoor, Soleen, Kluckert, Jonas, Rupp, Niels J., Eberli, Daniel, Hötker, Andreas M.
Format: Article
Language:English
Subjects:
Multiparametric MRI
PI-QUAL
PI-RADS
Prostate cancer
PSHS
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Summary:•Analysis of missed PCa and csPCa in men with prior negative mpMRI.•Significance of MR image quality scores (PI-QUAL, PSHS) and clinical parameters.•Lower PI-QUAL score is an independent predictor of missed csPCa.•Integration of image quality scoring systems into standard prostate MRI reports. To identify predictors of prostate cancer (PCa) and clinically significant prostate cancer (csPCa) in men with prior false-negative multiparametric MRI (mpMRI), focusing on image quality scoring systems and clinical parameters. In this IRB-approved retrospective single-center study, patients with a negative mpMRI (PI-RADS score ≤2) and subsequent prostate biopsies were included. Histopathological results served as reference standard. Welch’s t-Test was conducted to identify significant differences in image quality scores (PI-QUAL and PSHS) between patients with and without PCa/csPCA. In addition, clinical parameters (age, BMI, PSA density) and image quality scores (PI-QUAL and PSHS) were examined as potential predictors of PCa/csPCa detection after a false-negative mpMRI in uni- and multivariate analyses. Among 96 patients with negative mpMRI results, 44.8 % had PCa and 16.7 % had csPCa upon biopsy with histopathological confirmation. PI-QUAL scores were significantly lower in patients with PCa (p = 0.03) and csPCa (p = 0.005). PSHS scores were lower in patients with csPCa, but the difference was not statistically significant (p = 0.1). Higher age (p = 0.035) and a lower PI-QUAL score (p 
ISSN:0720-048X
1872-7727
DOI:10.1016/j.ejrad.2023.111227