Exploring the Involvement of Cytokines in Pediatric Patients Afflicted by Simple Febrile Seizures: A Case-Control Study

Aim: Most children under six with seizures experience febrile seizures (FS), which occur with a temperature of 38°C or higher and no apparent infectious or metabolic causes. FS has a multifaceted etiology, involving genetic and environmental factors. This study aimed to explore the connection betwee...

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Published in:Curēus (Palo Alto, CA) CA), 2023-10, Vol.15 (10), p.e48083-e48083
Main Authors: Vishal, Vaibhav, Sachdeva, Ashuma, Bhalla, Kapil, Dureja, Ankanksha, Tarte, Sagar
Format: Article
Language:English
Subjects:
Age
Blood
Brain research
Cerebrospinal fluid
Convulsions & seizures
Cytokines
Females
Fever
Hemoglobin
Immunology
Infections
Leukocytes
Males
Metabolism
Neutrophils
Pediatrics
Statistical analysis
Tumor necrosis factor-TNF
Viral infections
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Summary:Aim: Most children under six with seizures experience febrile seizures (FS), which occur with a temperature of 38°C or higher and no apparent infectious or metabolic causes. FS has a multifaceted etiology, involving genetic and environmental factors. This study aimed to explore the connection between the cytokine system (part of the immune system related to inflammation) and FS to uncover potential relationships.Method: This research was carried out on 50 patients experiencing FS and 25 patients experiencing only fever served as cases and controls, respectively. The patient’s blood was obtained under sterile circumstances from the antecubital/femoral vein as soon as feasible following the commencement of seizures. The complete hemogram analysis was done using the Mindray BC-5800 auto hematology analyzer (Mindray Medical International Limited, Shenzhen, China).Result: The cases group had significantly higher interleukin-4 (IL-4) concentrations (292.85 pg/mL) than controls (81.04 pg/mL), indicating a statistically significant difference (p
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.48083