Modular brain network in volitional eyes closing: enhanced integration with a marked impact on hubs

• Published in: Cerebral cortex (New York, N.Y. 1991) N.Y. 1991), 2024-01, Vol.34 (1)
• Main Authors: Zhang, Yi, Han, Xiao, Ge, Xuelian, Xu, Tianyong, Wang, Yanjie, Mu, Jiali, Liu, Fan
• Format: Article
• Language: English
• Subjects: Brain - diagnostic imaging; Brain Mapping; Cognition; Eye; Humans; Magnetic Resonance Imaging; Nerve Net - diagnostic imaging
• ISSN: 1047-3211; 1460-2199
• DOI: 10.1093/cercor/bhad464

Abstract Volitional eyes closing would shift brain’s information processing modes from the “exteroceptive” to “interoceptive” state. This transition induced by the eyes closing is underpinned by a large-scale reconfiguration of brain network, which is still not fully comprehended. Here, we investigated the eyes-closing-relevant network reconfiguration by examining the functional integration among intrinsic modules. Our investigation utilized a publicly available dataset with 48 subjects being scanned in both eyes closed and eyes open conditions. It was found that the modular integration was significantly enhanced during the eyes closing, including lower modularity index, higher participation coefficient, less provincial hubs, and more connector hubs. Moreover, the eyes-closing-enhanced integration was particularly noticeable in the hubs of network, mainly located in the default-mode network. Finally, the hub-dominant modular enhancement was positively correlated to the eyes-closing-reduced entropy of BOLD signal, suggesting a close connection to the diminished consciousness of individuals. Collectively, our findings strongly suggested that the enhanced modular integration with substantially reorganized hubs characterized the large-scale cortical underpinning of the volitional eyes closing.