Understanding the pathogenesis of engineered stone‐associated silicosis: The effect of particle chemistry on the lung cell response

Background and Objective The resurgence of severe and progressive silicosis among engineered stone benchtop industry workers is a global health crisis. We investigated the link between the physico‐chemical characteristics of engineered stone dust and lung cell responses to understand components that...

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Bibliographic Details
Published in:Respirology (Carlton, Vic.) Vic.), 2024-03, Vol.29 (3), p.217-227
Main Authors: Ramkissoon, Chandnee, Song, Yong, Yen, Seiha, Southam, Katherine, Page, Simone, Pisaniello, Dino, Gaskin, Sharyn, Zosky, Graeme R.
Format: Article
Language:English
Subjects:
Alveoli
Copper
Cytology
Cytotoxicity
Dust
dust particle characterization
engineered stone‐associated silicosis
Epithelial cells
Inflammation
lung assays
Macrophages
Metals
pathogenesis
Principal components analysis
Public health
Silica
Silicosis
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Summary:Background and Objective The resurgence of severe and progressive silicosis among engineered stone benchtop industry workers is a global health crisis. We investigated the link between the physico‐chemical characteristics of engineered stone dust and lung cell responses to understand components that pose the greatest risk. Methods Respirable dust from 50 resin‐based engineered stones, 3 natural stones and 2 non‐resin‐based materials was generated and analysed for mineralogy, morphology, metals, resin, particle size and charge. Human alveolar epithelial cells and macrophages were exposed in vitro to dust and assessed for cytotoxicity and inflammation. Principal component analysis and stepwise linear regression were used to explore the relationship between engineered stone components and the cellular response. Results Cutting engineered stone generated fine particles of
ISSN:1323-7799
1440-1843
1440-1843
DOI:10.1111/resp.14625