Effect of Campylobacter fetus on in vitro fertilization and embryonic development of preimplantation bovine embryos

Campylobacter fetus is an important veterinary pathogen that causes campylobacteriosis. This disease causes decreased productivity of cattle by inducing reproductive losses. Although several virulence factors have been recognized in C. fetus, including a cytolethal distending toxin (CDT), the exact...

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Bibliographic Details
Published in:Veterinary microbiology 2024-01, Vol.288, p.109925-109925, Article 109925
Main Authors: Cagnoli, Claudia Inés, Chiapparrone, María Laura, Cacciato, Claudio Santiago, Rodríguez, Marcelo Gastón, Catena, María Del Carmen, Aller, Juan Florencio
Format: Article
Language:English
Subjects:
Animals
Blastocyst
Campylobacter fetus
Campylobacter fetus subsp. fetus
Campylobacter Infections - veterinary
campylobacteriosis
Cattle
Cattle Diseases
embryogenesis
Embryonic Development
embryonic mortality
Female
Fertilization in Vitro - veterinary
microbiology
pathogens
Pregnancy
toxins
virulence
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Summary:Campylobacter fetus is an important veterinary pathogen that causes campylobacteriosis. This disease causes decreased productivity of cattle by inducing reproductive losses. Although several virulence factors have been recognized in C. fetus, including a cytolethal distending toxin (CDT), the exact mechanism responsible for embryonic death remains unknown. The aim of this work was to evaluate the effect of C. fetus subsp. fetus (Cff) and C. fetus subsp. venerealis (Cfv), and their toxin activity on the in vitro fertilization of bovine ova and early embryonic development. Two different experiments were performed. In Experiment 1, a total of 1524 cumulus-oocyte complexes (COCs) were inseminated, distributed into three groups: two of them infected with the microorganism (Cff, Cfv) and a control group. Percentages COCs cleaved were similar among groups (p = 0.1243); however, the embryonic development rate (blastocyst at day 7) in the control group was greater (p 
ISSN:0378-1135
1873-2542
DOI:10.1016/j.vetmic.2023.109925