A single atom cobalt anchored MXene bifunctional platform for rapid, label-free and high-throughput biomarker analysis and tissue imaging

Few of single-atom materials have been served as platform to analyze small molecules for surface assisted laser desorption/ionization mass spectrometry (SALDI-MS). Herein, a novel single Co atom-anchored MXene (Co-N-Ti C ) is prepared to achieve enhanced SALDI-MS and mass spectrometry imaging (MSI)...

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Published in:Biosensors & bioelectronics 2024-02, Vol.246, p.115903-115903, Article 115903
Main Authors: Liang, Weiqiang, Yan, Weining, Wang, Xiao, Yan, Xinfeng, Hu, Qiongzheng, Zhang, Wenqiang, Meng, Hongzheng, Yin, Luxu, He, Qing, Ma, Chunxia
Format: Article
Language:English
Subjects:
Biosensing Techniques
Cobalt
Humans
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods
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Summary:Few of single-atom materials have been served as platform to analyze small molecules for surface assisted laser desorption/ionization mass spectrometry (SALDI-MS). Herein, a novel single Co atom-anchored MXene (Co-N-Ti C ) is prepared to achieve enhanced SALDI-MS and mass spectrometry imaging (MSI) performance for the first time. The Co-N-Ti C films were prepared by a simple in situ self-assembly strategy to generate an efficient SALDI-MS platform. Compared to typical inorganic/organic matrices, Co-N-Ti C films exhibit superior performance in small molecules detection with ultra-high sensitivity (LOD at amol level), excellent repeatability (CV
ISSN:0956-5663
1873-4235
DOI:10.1016/j.bios.2023.115903