Exploring the impact of antibiotics, microplastics, nanoparticles, and pesticides on zebrafish gut microbiomes: Insights into composition, interactions, and health implications

• Published in: Chemosphere (Oxford) 2024-02, Vol.349, p.140867-140867, Article 140867
• Main Authors: Pamanji, Rajesh, Kumareshan, T.N., Priya S, Lakshmi, Sivan, Gisha, Selvin, Joseph
• Format: Article
• Language: English
• Subjects: Antibiotics; Dysbiosis; Gut microbiome; Microplastic; Nanoparticles; Pesticides; Zebrafish
• ISSN: 0045-6535; 1879-1298
• DOI: 10.1016/j.chemosphere.2023.140867

This review addresses the impact of various chemical entities like pesticides, antibiotics, nanoparticles and microplastic on gut microbiota of zebrafish. Gut microbiota plays a vital role in metabolic regulation in every organism. As majority of metabolic pathways coordinated by microbiota, small alterations associated with mild to serious outcomes. Because of their unstoppable usage in day-to-day life, the present-day research on gut microbiota is mostly comprising aforementioned chemicals. It is better to understand how gut microbiome is dysbiosed by various environmental factors, to keep our microbiota safe. We tried to delineate the natural flora of zebrafish gut microbiome and the metabolic and other pathways associated and what are the common flora that was dysbiosed during the treatment. Based on the existing literature, we reviewed pesticides like Imazalil, Difenoconazole, Chlorpyrifos, Metamifop, Carbendazim, Imidacloprid, Phoxim, Niclosamide, Dieldrin, and antibiotics like Oxytetracycline, Enrofloxacin, Florfenicol, Sulfamethoxazole, Tetracycline, Streptomycin, Doxycycline, and in the category of nanoparticles, Titanium dioxide nanoparticles (nTiO2), Abalone viscera hydrolysates decorated silver nanoparticles (AVH-AgNPs), Lead-halide perovskite nanoparticles (LHP NPs), Copper nanoparticles (Cu-NPs), silver nanoparticles (Ag-NPs) and microplastic types like polyethylene and polystyrene microplastic. Other studies with miscellaneous chemical entities on zebrafish gut microbiome include Ferulic acid, Polychlorinated biphenyls, Cadmium, Disinfection by-products, Triclosan, microcystin-LR, Fluoride, and Amitriptyline. [Display omitted] •This is an extensive review of gut microbiome dysbiosis in zebrafish in connection with various chemical entities.•Impact of antibiotics in gut microbiome dysbiosis was thoroughly investigated.•Highly synthesized and researched nanoparticles and their effects were delineated.•Polystyrene and polyethylene microplastic and nanoplastic induced gut microbiome dysbiosis was discussed.•Pesticides impact on gut microbiome and dysregulation of metabolic pathways were identified.