Follow-up assessment of sleep-related symptoms in patients after treatment for cancer: responses to continuous positive airway pressure treatment for co-morbid obstructive sleep apnoea

• Published in: Sleep & breathing 2024-05, Vol.28 (2), p.725-733
• Main Authors: Subramanian, Harini, Trivedi, Ritu, Fuchsova, Veronika, Elder, Elisabeth, Brand, Alison, Howle, Julie, Mann, Graham J., DeFazio, Anna, Amis, Terence, Kairaitis, Kristina
• Format: Article
• Language: English
• Subjects: Adult; Aged; Apnea; Breast cancer; Breast Neoplasms - complications; Breast Neoplasms - therapy; Comorbidity; Continuous Positive Airway Pressure; Dentistry; Endometrial cancer; Endometrial Neoplasms - complications; Endometrial Neoplasms - therapy; Endometrium; Female; Follow-Up Studies; Humans; Internal Medicine; Male; Mechanical ventilation; Medicine; Medicine & Public Health; Melanoma; Melanoma - complications; Melanoma - therapy; Middle Aged; Neurology; Otorhinolaryngology; Patients; Pediatrics; Pneumology/Respiratory System; Polysomnography; Questionnaires; Regression analysis; Sleep and wakefulness; Sleep apnea; Sleep Apnea, Obstructive - epidemiology; Sleep Apnea, Obstructive - therapy; Sleep Breathing Physiology and Disorders • Original Article; Sleep disorders; Sleep Quality; Uterine cancer
• ISSN: 1520-9512; 1522-1709; 1522-1709
• DOI: 10.1007/s11325-023-02946-6

Purpose To assess changes in sleep-related symptoms in patients with breast cancer, endometrial cancer and melanoma previously examined for sleep-related symptoms and the presence of PSG (polysomnography)-determined OSA, ≥ 3 years post-treatment; and to evaluate how CPAP treatment affects sleep-related symptoms in patients previously diagnosed with OSA. Methods Patients initially recruited from breast cancer, endometrial cancer, and melanoma follow-up clinics at Westmead Hospital (Sydney, Australia) participated in this questionnaire-based study. Demographic and change in cancer status data were collected at follow-up. Patients completed the Pittsburgh Sleep Quality Index [poor sleep quality, PSQI TOTAL  ≥ 5au], Insomnia Severity Index, Epworth Sleepiness Scale and Functional Outcomes of Sleep Questionnaire; with ΔPSQI TOTAL  ≥ 3au indicating a clinically meaningful change in sleep quality over follow-up. PSG-determined OSA was confirmed using the apnoea-hypopnoea index. CPAP compliance was determined via self-report (CPAP compliant, CPAP; not compliant, non-CPAP). Logistic regression models determined if changes in cancer status, AHI, cancer subgroup or CPAP treatment was predictive of ΔPSQI TOTAL  ≥ 3 au and p