Limonoids from the Branches and Leaves of Aglaia lawii and Their Cytotoxic Activities

Three undescribed limonoids (1–3), named aglaians G–I, and one new natural product azedaralide (4), together with nine known analogues (5–13) were isolated from the branches and leaves of Aglaia lawii by RP C18 column, silica gel column, Sephadex LH‐20 column chromatography and preparative HPLC. The...

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Bibliographic Details
Published in:Chemistry & biodiversity 2024-02, Vol.21 (2), p.e202301703-n/a
Main Authors: Dong, Jing‐Jing, Liu, Han‐Fei, Wang, Huan, Jiang, Tai‐Bai, Lou, Hua‐Yong, Li, Jin‐Yu, Pan, Wei‐Dong
Format: Article
Language:English
Subjects:
Aglaia lawii
Bioassays
Circular dichroism
Column chromatography
Crystallography
cytotoxic activities
Cytotoxicity
Dichroism
High performance liquid chromatography
Limonoids
Liquid chromatography
Natural products
NMR
Nuclear magnetic resonance
Silica
Silica gel
structure elucidation
Tumor cell lines
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Summary:Three undescribed limonoids (1–3), named aglaians G–I, and one new natural product azedaralide (4), together with nine known analogues (5–13) were isolated from the branches and leaves of Aglaia lawii by RP C18 column, silica gel column, Sephadex LH‐20 column chromatography and preparative HPLC. The structures of the new compounds were elucidated by IR, HRESIMS, 1D, 2D NMR, electronic circular dichroism (ECD) calculations and X‐ray crystallography diffraction analysis. The results of bioassay showed that the compound 12 exhibited potential inhibitory activity against six human tumor cell lines (MDA‐MB‐231, MCF‐7, Ln‐cap, A549, HeLa and HepG‐2) with IC50 values as 8.0–18.6 μM.
ISSN:1612-1872
1612-1880
DOI:10.1002/cbdv.202301703