Three-dimensional analysis reveals a high incidence of lung adenocarcinoma in the upper region

Purpose The lung is a unique organ with a ventilation-perfusion mismatch, which can cause inhomogeneous incidence rates of lung cancer depending on the location in the lung. We aimed to evaluate the incidence of lung adenocarcinoma in each lobe by analyzing the incidence per unit volume, to evaluate...

Full description

Saved in:
Bibliographic Details
Published in:Surgery today (Tokyo, Japan) Japan), 2024-06, Vol.54 (6), p.634-641
Main Authors: Kawamura, Tomoyuki, Sekine, Yasuharu, Sugai, Kazuto, Yanagihara, Takahiro, Saeki, Yusuke, Kitazawa, Shinsuke, Kobayashi, Naohiro, Goto, Yukinobu, Ichimura, Hideo, Ohigashi, Tomohiro, Maruo, Kazushi, Sato, Yukio
Format: Article
Language:English
Subjects:
Adenocarcinoma - epidemiology
Adenocarcinoma - pathology
Adenocarcinoma of Lung - epidemiology
Adenocarcinoma of Lung - pathology
Adult
Aged
Aged, 80 and over
Female
Humans
Imaging, Three-Dimensional
Incidence
Lung - pathology
Lung Neoplasms - epidemiology
Lung Neoplasms - pathology
Male
Medicine
Medicine & Public Health
Middle Aged
Original Article
Surgery
Surgical Oncology
Tomography, X-Ray Computed
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Purpose The lung is a unique organ with a ventilation-perfusion mismatch, which can cause inhomogeneous incidence rates of lung cancer depending on the location in the lung. We aimed to evaluate the incidence of lung adenocarcinoma in each lobe by analyzing the incidence per unit volume, to evaluate the incidence without being affected by differences in the size of each lobe or in the size of the lungs between individuals. Methods The number of adenocarcinomas in each lobe was counted. Lung volumes were measured using a three-dimensional computer workstation. The tumor incidence per unit volume was analyzed based on the number of tumors in each lobe. Results The number of tumors per unit volume was 0.467 in the right upper lobe (RUL), 0.182 in the right middle lobe, 0.209 in the right lower lobe, 0.306 in the left upper segment (LUS), 0.083 in the left lingular segment, and 0.169 in the left lower lobe. The tumor incidence rate of RUL + LUS was 2.269 times that of the other lobes, a value that was significantly higher when using the bootstrap method (p 
ISSN:0941-1291
1436-2813
DOI:10.1007/s00595-023-02776-9