Borohydride Ionic Liquids as Reductants of CO2 in the Selective N‐formylation of Amines

Borohydride imidazolium ionic liquids, [IL]BH4, used for the first time as reductants in the N‐formylation of various amines with CO2, provided an excellent yield of formamides. Under the same conditions, 5 bar CO2 and 80 °C, NaBH4 produced a mixture of N‐formylated and N‐methylated products in a ra...

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Bibliographic Details
Published in:ChemSusChem 2024-04, Vol.17 (7), p.e202301120-n/a
Main Authors: Pąchalska, Paulina, Skarżyńska, Anna, Matias, Ines A. S., Trzeciak, Anna M.
Format: Article
Language:English
Subjects:
amine-borane
Amines
Borohydrides
Carbon dioxide
ionic liquid
Ionic liquids
N-formylation
NMR
Nuclear magnetic resonance
Reducing agents
sodium borohydride
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Summary:Borohydride imidazolium ionic liquids, [IL]BH4, used for the first time as reductants in the N‐formylation of various amines with CO2, provided an excellent yield of formamides. Under the same conditions, 5 bar CO2 and 80 °C, NaBH4 produced a mixture of N‐formylated and N‐methylated products in a ratio of 1 : 2. An alternative approach, based on the addition of halide imidazolium salts ([IL]Cl or [IL]Br) to the reactions of amine with NaBH4 and CO2, resulted in a significant increase of selectivity to formamide. However, no effect was noted for [IL]BF4 and [IL]PF6. Monitoring the reaction course in time using 1H NMR brought about new insight into the role of BH3 in the reduction of CO2 and the functionalization of amines. The formation of N‐methylaniline – borane intermediate was evidenced. Ionics to the rescue! Borohydride ionic liquids [IL]BH4 are used as reductants in the reaction of amines with CO2 provide highly selective formation of formamides.
ISSN:1864-5631
1864-564X
DOI:10.1002/cssc.202301120