Sterically demanding Csp2(ortho-substitution)–Csp3(tertiary) bond formation via carboxylate-directed Mizoroki-Heck reaction under extra-ligand-free conditions

Construction of the sterically demanding Csp2(oS)–Csp3(T) bond was achieved by carrying out the Pd-catalyzed carboxylate-directed Mizoroki-Heck reaction under extra-ligand-free aqueous conditions. The cooperative role of the presence of water with the absence of phosphine ligand was proposed to acce...

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Bibliographic Details
Published in:Organic & biomolecular chemistry 2023-12, Vol.22 (1), p.80-84
Main Authors: Zeng, Wei, Ai-Wen, Chen, Ming-Jie, Yan, Wang, Jie
Format: Article
Language:English
Subjects:
Ligands
Phosphine
Phosphines
Substitution reactions
Substrates
Online Access:Get full text
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Summary:Construction of the sterically demanding Csp2(oS)–Csp3(T) bond was achieved by carrying out the Pd-catalyzed carboxylate-directed Mizoroki-Heck reaction under extra-ligand-free aqueous conditions. The cooperative role of the presence of water with the absence of phosphine ligand was proposed to accelerate the migratory insertion process considerably, delivering a broad substrate scope.
ISSN:1477-0520
1477-0539
DOI:10.1039/d3ob01784b