Dysregulation of DNA epigenetic modulators during prostate carcinogenesis in an eastern Indian patient population: Prognostic implications

The role of epigenetic alteration in prostate cancer pathogenesis was reported. We aimed to analyze dysregulation of DNA methylase (DNA methyl transferase/DNMT) and demethylase (ten eleven translocase/TET) and the associated interplay between them during prostate tumorigenesis. Promoter methylation...

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Bibliographic Details
Published in:Pathology, research and practice research and practice, 2024-01, Vol.253, p.154970-154970, Article 154970
Main Authors: Banerjee, Anwesha, Bardhan, Abhishek, Sarkar, Purandar, Datta, Chhanda, Pal, Dilip Kumar, Saha, Abhik, Ghosh, Amlan
Format: Article
Language:English
Subjects:
5hmC
Bone metastasis
DNMT
Epigenetic alteration
Prostate cancer
TET
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Summary:The role of epigenetic alteration in prostate cancer pathogenesis was reported. We aimed to analyze dysregulation of DNA methylase (DNA methyl transferase/DNMT) and demethylase (ten eleven translocase/TET) and the associated interplay between them during prostate tumorigenesis. Promoter methylation and RNA/protein expression of selected DNMT and TETs were analysed in normal prostate, benign prostatic hyperplasia (BPH), and prostate cancer (PCa). Genomic 5-hydroxymethylcytosine (5hmC) level was detected and correlated with DNMT and TET proteins. Clinicopathological association of molecular data was done. Our data revealed a very low frequency of promoter methylation for DNMT1 (5-3% and high frequency for TET1 (22–38%), TET2 (68–90 %), and TET3 (43-32 %) in BPH and PCa. The promoter methylation of DNMT1 (p = 0.019) showed a significantly decreasing trend, while that of TET1 (p = 0.0005) and TET2 (p 
ISSN:0344-0338
1618-0631
DOI:10.1016/j.prp.2023.154970