Assessment of antiarthritic potential of Asparagus dumosus using formaldehyde and CFA-induced arthritic models in rats via modulation of oxidative stress biomarkers and mRNA expression of IL-1b, IL-6, RANKL, OPG, TNF-α and COX-2

Medicinal plants play a pivotal role in the prevention of chronic non-communicable diseases including arthritis. Despite the traditional use of Asparagus dumosus in arthritis, it has not been studied yet for its effectiveness in arthritis. This study was aimed to explore the antiarthritic potential...

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Bibliographic Details
Published in:Inflammopharmacology 2024-02, Vol.32 (1), p.825-847
Main Authors: Nazar, Nimra, Mehmood, Malik Hassan, Siddique, Rida, Faisal, Muhammad Naeem
Format: Article
Language:English
Subjects:
Allergology
Animals
Arthritis
Benzaldehydes
Biomarkers
Biomedical and Life Sciences
Biomedicine
Cyclooxygenase 2 - genetics
Dermatology
Formaldehyde
Freund's Adjuvant
Gastroenterology
Hydrogen Peroxide
Immunology
Interleukin-6
Original Article
Oxidative Stress
Pharmacology/Toxicology
Rats
Rheumatology
RNA, Messenger - genetics
Tumor Necrosis Factor-alpha - genetics
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Summary:Medicinal plants play a pivotal role in the prevention of chronic non-communicable diseases including arthritis. Despite the traditional use of Asparagus dumosus in arthritis, it has not been studied yet for its effectiveness in arthritis. This study was aimed to explore the antiarthritic potential of A. dumosus in formaldehyde and complete Freund’s adjuvant (CFA)-induced arthritic rats. Body weight, arthritic index, hepatic oxidative stress, hematological, biochemical and inflammatory markers were assessed using ELISA, whilst qRT-PCR studies were carried out for the mRNA expression of IL-1b, IL-6, RANKL, OPG, TNF-α and COX-2 genes. GCMS and HPLC analysis were performed to identify the secondary metabolites of A. dumosus . From day 8 to 28 post-administration of formaldehyde and CFA, oral administration of A. dumosus (600, 300 and 150 mg/kg) showed a noteworthy improvement ( p  
ISSN:0925-4692
1568-5608
DOI:10.1007/s10787-023-01391-x