mTOR takes charge: Relaying uncharged tRNA levels by mTOR ubiquitination

Nutrient availability is conveyed to the mechanistic target of rapamycin (mTOR), which couples metabolic processes with cell growth and proliferation. How mTOR itself is modulated by amino acid levels remains poorly understood. Ge and colleagues now demonstrate that broad sensing of uncharged tRNAs...

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Bibliographic Details
Published in:Cell metabolism 2023-12, Vol.35 (12), p.2097-2099
Main Author: Jacinto, Estela
Format: Article
Language:English
Subjects:
Mechanistic Target of Rapamycin Complex 1 - metabolism
Mechanistic Target of Rapamycin Complex 2 - genetics
Mechanistic Target of Rapamycin Complex 2 - metabolism
RNA, Transfer - metabolism
Signal Transduction - physiology
TOR Serine-Threonine Kinases - metabolism
Ubiquitination
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Summary:Nutrient availability is conveyed to the mechanistic target of rapamycin (mTOR), which couples metabolic processes with cell growth and proliferation. How mTOR itself is modulated by amino acid levels remains poorly understood. Ge and colleagues now demonstrate that broad sensing of uncharged tRNAs by GCN2/FBXO22 inactivates mTOR complex 1 (mTORC1) via mTOR ubiquitination.
ISSN:1550-4131
1932-7420
1932-7420
DOI:10.1016/j.cmet.2023.11.006