Emerging functions and significance of circCDYL in human disorders

• Published in: Molecular biology reports 2024-12, Vol.51 (1), p.7-7, Article 7
• Main Authors: Khalilian, Sheyda, Tabari, Mohammad Amin Khazeei, Omrani, Mohammad Amin, Ghafouri-Fard, Soudeh
• Format: Article
• Language: English
• Subjects: Adult; aneurysm; Animal Anatomy; Animal Biochemistry; Aortic aneurysms; Binding sites; Biomedical and Life Sciences; Bladder cancer; Breast cancer; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Cell growth; Circular RNA; Colon cancer; Colorectal cancer; colorectal neoplasms; Cytoplasm; Diabetes mellitus; exons; Female; Gene expression; gene expression regulation; Gestational diabetes; Heart attacks; Hepatocellular carcinoma; hepatoma; Histology; Humans; Internal ribosome entry site; internal ribosome entry sites; kidney diseases; Kidney Neoplasms; Life Sciences; Liver cancer; Lung cancer; lung neoplasms; Lung Neoplasms - genetics; Lymphoma; Mantle cell lymphoma; Medical research; Membranous nephropathy; MicroRNAs; MicroRNAs - genetics; Molecular biology; Morphology; Multiple myeloma; myeloma; Myocardial infarction; Nephropathy; Non-small cell lung carcinoma; Pathophysiology; Proteins; Review; Ribonucleic acid; RNA; RNA, Circular - genetics; Roles; Small cell lung carcinoma; urinary bladder neoplasms
• ISSN: 0301-4851; 1573-4978
• DOI: 10.1007/s11033-023-08993-2

Circular RNAs (circRNAs) are a group of non-coding transcripts in which a loop structure is shaped via a back splicing procedure. They have central roles in the regulation of gene expression. hsa_circ_0008285, alternatively named as circCDYL, is a circular RNA originated from the exon 4 of CDYL gene. It is produced by a back-splice incident and is mainly located in the cytoplasm. It has no internal ribosome entry site, open reading frame and intronic sequences. CircCDYL dysregulation has been reported in the malignant conditions including multiple myeloma, mantle cell lymphoma, breast cancer, non-small cell lung cancer, Wilms tumor, bladder cancer, colon cancer, and hepatocellular carcinoma. It also has an emerging role in the pathophysiology of non-malignant conditions including myocardial infarction, gestational diabetes mellitus, membranous nephropathy, and abdominal aortic aneurysm. In the current study, we summarize the emerging roles of circCDYL in malignant and non-malignant conditions.