Effect of albumin infusion on oxidative albumin modification and albumin binding capacity in chronic liver failure

• Published in: Basic & clinical pharmacology & toxicology 2024-03, Vol.134 (3), p.375-384
• Main Authors: Stauber, Rudolf E., Paar, Margret, Balazs, Irina, Horvath, Angela, Feldbacher, Nicole, Posch, Andreas, Rainer, Florian, Stadlbauer, Vanessa, Oettl, Karl
• Format: Article
• Language: English
• Subjects: Albumin; albumin binding capacity; Albumins; Binding; Cirrhosis; Failure; human mercaptalbumin; human nonmercaptalbumin‐1; human nonmercaptalbumin‐2; Liver; Liver cirrhosis; neutrophil function; Redox properties
• ISSN: 1742-7835; 1742-7843
• DOI: 10.1111/bcpt.13973

Oxidative albumin modification and impaired albumin binding function have been described both in chronic liver failure and for therapeutic albumin solutions. The aim of the present study was to evaluate the effect of albumin infusion on redox state and binding function of circulating albumin. We studied 20 patients with cirrhosis who routinely received albumin infusions for prevention of post‐paracentesis circulatory dysfunction or treatment of hepatorenal syndrome. We measured albumin fractions by redox state of cysteine‐34 and albumin binding properties using dansylsarcosine as site II ligand. Therapeutic albumin solutions showed high contents of human nonmercaptalbumin‐1 and human nonmercaptalbumin‐2, exceeding the respective values in our patients with decompensated cirrhosis. An initial protocol for the first nine patients sampled at baseline, 24 h and 48 h after albumin infusion revealed no significant changes of oxidized albumin species or albumin binding properties. However, a modified protocol for the remaining 11 patients sampled at baseline,