Impact of pregnancy vaccine uptake and socio-demographic determinants on subsequent childhood Measles, Mumps and Rubella vaccine uptake: A UK birth cohort study

•Children living in deprived vs affluent areas are >10 % less likely to be vaccinated.•Mothers vaccinated in pregnancy vs unvaccinated 40% more likely to vaccinate child.•Pregnancy is an opportunity to promote both maternal & childhood vaccines to parents. We examined the association between...

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Bibliographic Details
Published in:Vaccine 2024-01, Vol.42 (2), p.322-331
Main Authors: Skirrow, H, Foley, K, Bedford, H, Lewis, C, Whittaker, E, Costelloe, C, Saxena, S
Format: Article
Language:English
Subjects:
Age
Birth order
Childhood
Children
Children & youth
Cohort analysis
COVID-19 vaccines
Demographics
Demography
Deprivation
Epidemics
Ethnicity
Families & family life
Immunization
Influenza
Measles
Minority & ethnic groups
MMR vaccine
Mumps
Pertussis
Pregnancy
Pregnancy vaccines
Primary care
Public health
Rubella
Socio-demographic determinants
Sociodemographics
Statistical models
Vaccine uptake
Vaccines
Whooping cough
Womens health
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Summary:•Children living in deprived vs affluent areas are >10 % less likely to be vaccinated.•Mothers vaccinated in pregnancy vs unvaccinated 40% more likely to vaccinate child.•Pregnancy is an opportunity to promote both maternal & childhood vaccines to parents. We examined the association between socio-demographic determinants and uptake of childhood Measles, Mumps & Rubella (MMR) vaccines and the association between pregnant women’s pertussis vaccine uptake and their children’s MMR vaccine uptake. We used nationally-representative linked mother-baby electronic records from the United Kingdom’s Clinical-Practice-Research-Datalink. We created a birth cohort of children born between 01.01.2000 and 12.12.2020. We estimated the proportion vaccinated with first MMR vaccine by age 2 years and first and second MMR vaccines by age 5 years. We used survival-analysis and Cox proportional hazard models to examine the association between deprivation, ethnicity and maternal age and pertussis vaccination in pregnancy and children’s MMR uptake. Overall, 89.4 % (710,797/795,497) of children had first MMR by age 2 years and 92.6 % (736,495/795,497) by age 5 years. Among children still in the cohort when second MMR was due, 85.9 % (478,480/557,050) had two MMRs by age 5 years. Children from the most-deprived areas, children of Black ethnicity and children of mothers aged 
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2023.11.063