Tellimagrandin-I and camptothin a exhibit chemopreventive effects in Salmonella enterica serovar Typhimurium strains and human lymphocytes

Tellimagrandin-I (TL) and camptothin A (CA) are ellagitannins widely found in diverse plant species. Numerous studies demonstrated their significant biological activities, which include antitumor, antioxidant, and hepatoprotective properties. Despite this protective profile, the effects of TL and CA...

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Published in:Journal of Toxicology and Environmental Health, Part A Part A, 2024-03, Vol.87 (5), p.185-198
Main Authors: Fernandes, Amanda Silva, de Melo Bisneto, Abel Vieira, Silva, Luana Santos, Flávia Luiz Cardoso Bailão, Elisa, Cardoso, Clever Gomes, Carneiro, Cristiene Costa, da Costa Santos, Suzana, Chen-Chen, Lee
Format: Article
Language:English
Subjects:
Ames test
Anticancer properties
CometChip
Cytotoxicity
Damage
Deoxyribonucleic acid
DNA
DNA damage
DNA protection
Doxorubicin
Ellagitannins
Genotoxicity
Lymphocytes
Mutagens
phytochemical compounds
Plant species
Salmonella
Salmonella enterica
Sodium azide
Sodium azides
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Summary:Tellimagrandin-I (TL) and camptothin A (CA) are ellagitannins widely found in diverse plant species. Numerous studies demonstrated their significant biological activities, which include antitumor, antioxidant, and hepatoprotective properties. Despite this protective profile, the effects of TL and CA on DNA have not been comprehensively investigated. Thus, the aim of this study was to determine the mutagenic and antimutagenic effects attributed to TL and CA exposure on Salmonella enterica serovar Typhimurium strains using the Ames test. In addition, the cytotoxic and genotoxic effects were examined on human lymphocytes, employing both trypan blue exclusion and CometChip assay. The antigenotoxic effect was determined following TL and CA exposure in the presence of co-treatment with doxorubicin (DXR). Our results from the Ames test indicated that TL or CA did not display marked mutagenic activity. However, TL or CA demonstrated an ability to protect DNA against the damaging effects of the mutagens 4-nitroquinoline-1-oxide and sodium azide, thereby exhibiting antimutagenic properties. In relation to human lymphocytes, TL or CA did not induce significant cytotoxic or genotoxic actions on these cells. Further, these ellagitannins exhibited an ability to protect DNA from damage induced by DOX during co-treatment, indicating their potential beneficial usefulness as antigenotoxic agents. In conclusion, the protective effects of TL or CA against mutagens, coupled with their absence of genotoxic and cytotoxic effects on human lymphocytes, emphasize their potential therapeutic value in chemopreventive strategies.
ISSN:1528-7394
1087-2620
2381-3504
DOI:10.1080/15287394.2023.2290641