Respiratory torque teno virus load at emergency department visit predicts intensive care unit admission of SARS‐CoV‐2 infected patients

Accurate prediction of COVID‐19 severity remains a challenge. Torque teno virus (TTV), recognized as a surrogate marker of functional immunity in solid organ transplant recipients, holds the potential for assessing infection outcomes. We investigated whether quantifying TTV in nasopharyngeal samples...

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Bibliographic Details
Published in:Journal of medical virology 2023-12, Vol.95 (12), p.e29319-n/a
Main Authors: Feghoul, Linda, Caillault, Amandine, Peyrony, Olivier, Salmona, Maud, Nere, Marie‐Laure, Delaugerre, Constance, Azoulay, Elie, Chevret, Sylvie, LeGoff, Jérôme
Format: Article
Language:English
Subjects:
anellovirus
COVID-19
Deoxyribonucleic acid
Diabetes mellitus
DNA
Dyspnea
Emergency medical care
Emergency medical services
Hepatitis
Immunosuppression
Intensive care
Multivariate analysis
Oxygen requirement
Patients
SARS‐CoV‐2
Severe acute respiratory syndrome
Severe acute respiratory syndrome coronavirus 2
Torque
torque teno virus
Viral diseases
Virology
Viruses
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Summary:Accurate prediction of COVID‐19 severity remains a challenge. Torque teno virus (TTV), recognized as a surrogate marker of functional immunity in solid organ transplant recipients, holds the potential for assessing infection outcomes. We investigated whether quantifying TTV in nasopharyngeal samples upon emergency department (ED) admission could serve as an early predictor of COVID‐19 severity. Retrospective single‐center study in the ED of Saint‐Louis Hospital in Paris, France. TTV DNA was quantified in nasopharyngeal swab samples collected for SARS‐CoV‐2 testing. Among 295 SARS‐CoV‐2 infected patients, 92 returned home, 160 were admitted to medical wards, and 43 to the intensive care unit (ICU). Elevated TTV loads were observed in ICU patients (median: 3.02 log copies/mL, interquartile range [IQR]: 2.215–3.825), exceeding those in discharged (2.215, [0; 2.962]) or hospitalized patients (2.24, [0; 3.29]) (p = 0.006). Multivariate analysis identified diabetes, obesity, hepatitis, fever, dyspnea, oxygen requirement, and TTV load as predictors of ICU admission. A 2.91 log10 copies/mL TTV threshold independently predicted ICU admission. Nasopharyngeal TTV quantification in SARS‐CoV‐2 infected patients is linked to the likelihood of ICU admission and might reflect respiratory immunosuppression.
ISSN:0146-6615
1096-9071
DOI:10.1002/jmv.29319