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PVA-based bulk microneedles capable of high insulin loading and pH-triggered degradation for multi-responsive and sustained hypoglycemic therapy
"Closed-loop" insulin-loaded microneedle patche shows great promise for improving therapeutic outcomes and life quality for diabetes patients. However, it is typically hampered by limited insulin loading capacity, random degradation, and intricate preparation procedures for the independenc...
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| Published in: | Biomaterials science 2024-01, Vol.12 (2), p.57-517 |
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| container_end_page | 517 |
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| container_title | Biomaterials science |
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| creator | Ma, Yuhong Wang, Wei He, Mujiao Liu, Yunzhu Li, Caihua Zhong, Yinan Bu, Quanmin Huang, Dechun Qian, Hongliang Chen, Wei |
| description | "Closed-loop" insulin-loaded microneedle patche shows great promise for improving therapeutic outcomes and life quality for diabetes patients. However, it is typically hampered by limited insulin loading capacity, random degradation, and intricate preparation procedures for the independence of the "closed-loop" bulk microneedles. In this study, we combined the solubility of microneedles and "closed-loop" systems and designed poly(vinyl alcohol)-based bulk microneedles (MNs@GI) through
in situ
photopolymerization for multi-responsive and sustained hypoglycemic therapy, which significantly simplified the preparation process and improved insulin loading. GOx/insulin co-encapsulated MNs@GI with a phenylboronic ester structure improved glycemic responsiveness to control the insulin release under high glucose conditions and reduced inflammation risk in the normal skin. MNs@GI could further degrade to increase insulin release due to the crosslinked acetal-linkage hydrolysis in the presence of gluconic acid, which was caused by GOx-mediated glucose-oxidation in a hyperglycemic environment. The
in vivo
results showed that MNs@GI effectively regulated glycemic levels within the normal range for approximately 10 h compared to that of only insulin-loaded microneedles (MNs@INS). Consequently, the highly insulin-loaded, multi-responsive, and pH-triggered MN system has tremendous potential for diabetes treatment.
"Closed-loop" insulin-loaded microneedle patches show great promise for improving therapeutic outcomes and life quality for diabetes patients. |
| doi_str_mv | 10.1039/d3bm01760e |
| format | article |
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in situ
photopolymerization for multi-responsive and sustained hypoglycemic therapy, which significantly simplified the preparation process and improved insulin loading. GOx/insulin co-encapsulated MNs@GI with a phenylboronic ester structure improved glycemic responsiveness to control the insulin release under high glucose conditions and reduced inflammation risk in the normal skin. MNs@GI could further degrade to increase insulin release due to the crosslinked acetal-linkage hydrolysis in the presence of gluconic acid, which was caused by GOx-mediated glucose-oxidation in a hyperglycemic environment. The
in vivo
results showed that MNs@GI effectively regulated glycemic levels within the normal range for approximately 10 h compared to that of only insulin-loaded microneedles (MNs@INS). Consequently, the highly insulin-loaded, multi-responsive, and pH-triggered MN system has tremendous potential for diabetes treatment.
"Closed-loop" insulin-loaded microneedle patches show great promise for improving therapeutic outcomes and life quality for diabetes patients.</description><identifier>ISSN: 2047-4830</identifier><identifier>EISSN: 2047-4849</identifier><identifier>DOI: 10.1039/d3bm01760e</identifier><identifier>PMID: 38088652</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Closed loops ; Degradation ; Diabetes ; Gluconic acid ; Glucose ; Insulin ; Needles ; Oxidation ; Photopolymerization ; Polyvinyl alcohol</subject><ispartof>Biomaterials science, 2024-01, Vol.12 (2), p.57-517</ispartof><rights>Copyright Royal Society of Chemistry 2024</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c337t-a5d681fd27b3ecc9b985cba9d16cc8979c0035ad7b6dc81fcee9332cd7d6f05d3</citedby><cites>FETCH-LOGICAL-c337t-a5d681fd27b3ecc9b985cba9d16cc8979c0035ad7b6dc81fcee9332cd7d6f05d3</cites><orcidid>0000-0003-4683-3940 ; 0000-0002-0303-5888 ; 0000-0003-4017-9722</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38088652$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ma, Yuhong</creatorcontrib><creatorcontrib>Wang, Wei</creatorcontrib><creatorcontrib>He, Mujiao</creatorcontrib><creatorcontrib>Liu, Yunzhu</creatorcontrib><creatorcontrib>Li, Caihua</creatorcontrib><creatorcontrib>Zhong, Yinan</creatorcontrib><creatorcontrib>Bu, Quanmin</creatorcontrib><creatorcontrib>Huang, Dechun</creatorcontrib><creatorcontrib>Qian, Hongliang</creatorcontrib><creatorcontrib>Chen, Wei</creatorcontrib><title>PVA-based bulk microneedles capable of high insulin loading and pH-triggered degradation for multi-responsive and sustained hypoglycemic therapy</title><title>Biomaterials science</title><addtitle>Biomater Sci</addtitle><description>"Closed-loop" insulin-loaded microneedle patche shows great promise for improving therapeutic outcomes and life quality for diabetes patients. However, it is typically hampered by limited insulin loading capacity, random degradation, and intricate preparation procedures for the independence of the "closed-loop" bulk microneedles. In this study, we combined the solubility of microneedles and "closed-loop" systems and designed poly(vinyl alcohol)-based bulk microneedles (MNs@GI) through
in situ
photopolymerization for multi-responsive and sustained hypoglycemic therapy, which significantly simplified the preparation process and improved insulin loading. GOx/insulin co-encapsulated MNs@GI with a phenylboronic ester structure improved glycemic responsiveness to control the insulin release under high glucose conditions and reduced inflammation risk in the normal skin. MNs@GI could further degrade to increase insulin release due to the crosslinked acetal-linkage hydrolysis in the presence of gluconic acid, which was caused by GOx-mediated glucose-oxidation in a hyperglycemic environment. The
in vivo
results showed that MNs@GI effectively regulated glycemic levels within the normal range for approximately 10 h compared to that of only insulin-loaded microneedles (MNs@INS). Consequently, the highly insulin-loaded, multi-responsive, and pH-triggered MN system has tremendous potential for diabetes treatment.
"Closed-loop" insulin-loaded microneedle patches show great promise for improving therapeutic outcomes and life quality for diabetes patients.</description><subject>Closed loops</subject><subject>Degradation</subject><subject>Diabetes</subject><subject>Gluconic acid</subject><subject>Glucose</subject><subject>Insulin</subject><subject>Needles</subject><subject>Oxidation</subject><subject>Photopolymerization</subject><subject>Polyvinyl alcohol</subject><issn>2047-4830</issn><issn>2047-4849</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNpd0ctO3DAUBmCrKioI2HTfylI3FVKoHU_ieEmHqwRqF223kS8nGYNjBztBmrfgkTEMHSS8sSV_PufIP0KfKTmmhIkfhqmBUF4T-ID2SrLgxaJZiI_bMyO76DClW5IX54LU9BPaZQ1pmroq99Dj738nhZIJDFazu8OD1TF4AOMgYS1HqRzg0OGV7VfY-jQ767EL0ljfY-kNHi-LKdq-h5hLGOijNHKyweMuRDzMbrJFhDQGn-wDvLxIc5qk9Zmv1mPo3VpD7oqnFUQ5rg_QTiddgsPXfR_9PT_7s7wsrn9dXC1PrgvNGJ8KWZm6oZ0puWKgtVCiqbSSwtBa60ZwoQlhlTRc1UZnqAEEY6U23NQdqQzbR983dccY7mdIUzvYpME56SHMqS0FKcWiJKTK9Ns7ehvm6PN0WdGK5k5lk9XRRuUPTClC147RDjKuW0ra56jaU_bz5iWqs4y_vpac1QBmS_8Hk8GXDYhJb2_fsmZPlHebMA</recordid><startdate>20240116</startdate><enddate>20240116</enddate><creator>Ma, Yuhong</creator><creator>Wang, Wei</creator><creator>He, Mujiao</creator><creator>Liu, Yunzhu</creator><creator>Li, Caihua</creator><creator>Zhong, Yinan</creator><creator>Bu, Quanmin</creator><creator>Huang, Dechun</creator><creator>Qian, Hongliang</creator><creator>Chen, Wei</creator><general>Royal Society of Chemistry</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-4683-3940</orcidid><orcidid>https://orcid.org/0000-0002-0303-5888</orcidid><orcidid>https://orcid.org/0000-0003-4017-9722</orcidid></search><sort><creationdate>20240116</creationdate><title>PVA-based bulk microneedles capable of high insulin loading and pH-triggered degradation for multi-responsive and sustained hypoglycemic therapy</title><author>Ma, Yuhong ; Wang, Wei ; He, Mujiao ; Liu, Yunzhu ; Li, Caihua ; Zhong, Yinan ; Bu, Quanmin ; Huang, Dechun ; Qian, Hongliang ; Chen, Wei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c337t-a5d681fd27b3ecc9b985cba9d16cc8979c0035ad7b6dc81fcee9332cd7d6f05d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Closed loops</topic><topic>Degradation</topic><topic>Diabetes</topic><topic>Gluconic acid</topic><topic>Glucose</topic><topic>Insulin</topic><topic>Needles</topic><topic>Oxidation</topic><topic>Photopolymerization</topic><topic>Polyvinyl alcohol</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ma, Yuhong</creatorcontrib><creatorcontrib>Wang, Wei</creatorcontrib><creatorcontrib>He, Mujiao</creatorcontrib><creatorcontrib>Liu, Yunzhu</creatorcontrib><creatorcontrib>Li, Caihua</creatorcontrib><creatorcontrib>Zhong, Yinan</creatorcontrib><creatorcontrib>Bu, Quanmin</creatorcontrib><creatorcontrib>Huang, Dechun</creatorcontrib><creatorcontrib>Qian, Hongliang</creatorcontrib><creatorcontrib>Chen, Wei</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>MEDLINE - Academic</collection><jtitle>Biomaterials science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ma, Yuhong</au><au>Wang, Wei</au><au>He, Mujiao</au><au>Liu, Yunzhu</au><au>Li, Caihua</au><au>Zhong, Yinan</au><au>Bu, Quanmin</au><au>Huang, Dechun</au><au>Qian, Hongliang</au><au>Chen, Wei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>PVA-based bulk microneedles capable of high insulin loading and pH-triggered degradation for multi-responsive and sustained hypoglycemic therapy</atitle><jtitle>Biomaterials science</jtitle><addtitle>Biomater Sci</addtitle><date>2024-01-16</date><risdate>2024</risdate><volume>12</volume><issue>2</issue><spage>57</spage><epage>517</epage><pages>57-517</pages><issn>2047-4830</issn><eissn>2047-4849</eissn><abstract>"Closed-loop" insulin-loaded microneedle patche shows great promise for improving therapeutic outcomes and life quality for diabetes patients. However, it is typically hampered by limited insulin loading capacity, random degradation, and intricate preparation procedures for the independence of the "closed-loop" bulk microneedles. In this study, we combined the solubility of microneedles and "closed-loop" systems and designed poly(vinyl alcohol)-based bulk microneedles (MNs@GI) through
in situ
photopolymerization for multi-responsive and sustained hypoglycemic therapy, which significantly simplified the preparation process and improved insulin loading. GOx/insulin co-encapsulated MNs@GI with a phenylboronic ester structure improved glycemic responsiveness to control the insulin release under high glucose conditions and reduced inflammation risk in the normal skin. MNs@GI could further degrade to increase insulin release due to the crosslinked acetal-linkage hydrolysis in the presence of gluconic acid, which was caused by GOx-mediated glucose-oxidation in a hyperglycemic environment. The
in vivo
results showed that MNs@GI effectively regulated glycemic levels within the normal range for approximately 10 h compared to that of only insulin-loaded microneedles (MNs@INS). Consequently, the highly insulin-loaded, multi-responsive, and pH-triggered MN system has tremendous potential for diabetes treatment.
"Closed-loop" insulin-loaded microneedle patches show great promise for improving therapeutic outcomes and life quality for diabetes patients.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>38088652</pmid><doi>10.1039/d3bm01760e</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0003-4683-3940</orcidid><orcidid>https://orcid.org/0000-0002-0303-5888</orcidid><orcidid>https://orcid.org/0000-0003-4017-9722</orcidid></addata></record> |
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| ispartof | Biomaterials science, 2024-01, Vol.12 (2), p.57-517 |
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| language | eng |
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| source | Royal Society of Chemistry Journals |
| subjects | Closed loops Degradation Diabetes Gluconic acid Glucose Insulin Needles Oxidation Photopolymerization Polyvinyl alcohol |
| title | PVA-based bulk microneedles capable of high insulin loading and pH-triggered degradation for multi-responsive and sustained hypoglycemic therapy |
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