Cancer Cachexia: New Insights and Future Directions

Cancer remains a major health problem and is associated with cachexia in up to 80% of cases, leading to decreased survival and quality of life. Cachexia involves complex metabolic disturbances in both protein and energy balance, muscle wasting phenomena, weight loss, systemic inflammation, overall d...

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Bibliographic Details
Published in:Cancers 2023-11, Vol.15 (23), p.5590
Main Authors: Mariean, Claudia Raluca, Tiucă, Oana Mirela, Mariean, Alexandru, Cotoi, Ovidiu Simion
Format: Article
Language:English
Subjects:
Anorexia
B cells
Biomarkers
Body mass index
Cachexia
Cancer
Chronic illnesses
Development and progression
Diagnosis
Disease
Energy balance
Inflammation
Insulin resistance
Malnutrition
Medical diagnosis
Metabolism
Muscle strength
Musculoskeletal system
Oncology, Experimental
Patients
Prognosis
Proteins
Quality of life
Sarcopenia
Survival
Toxicity
Weight loss
Womens health
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Summary:Cancer remains a major health problem and is associated with cachexia in up to 80% of cases, leading to decreased survival and quality of life. Cachexia involves complex metabolic disturbances in both protein and energy balance, muscle wasting phenomena, weight loss, systemic inflammation, overall decreased performance status, and tolerability to treatment. The clinical impact of cancer cachexia is very complex, with early detection of cachectic patients and identification of predictive biomarkers being two key factors for improving survival. Thus, a better understanding of the complexity of cancer cachexia phenomena and its main pathophysiological mechanism is much needed. Our review highlights the most important information about cancer cachexia, aiming to disseminate updated research findings about this highly deadly condition.
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers15235590