Increased Risk of Alzheimer's Disease in Patients with Head and Neck Cancer

Patients with head and neck cancer (HNC) often experience cognitive impairment. However, the relationship between cancer and Alzheimer's disease (AD) remains unclear. We aimed to elucidate the relationship between patients with HNC and their subsequent AD development. This retrospective study u...

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Bibliographic Details
Published in:Cancers 2023-11, Vol.15 (23), p.5516
Main Authors: Lee, Il Hwan, Yu, Hyunjae, Ha, Seung-Su, Yang, Hee Gyu, Kim, Dong-Kyu
Format: Article
Language:English
Subjects:
Advertising executives
Alzheimer's disease
Cancer
Cancer patients
Cancer therapies
Care and treatment
Codes
Cognitive ability
Comorbidity
Consent
Datasets
Dementia
Development and progression
Diagnosis
Disease
Head & neck cancer
Head and neck cancer
Independent variables
Larynx
Medical diagnosis
National health insurance
Neurodegenerative diseases
Oncology, Experimental
Oral carcinoma
Oral cavity
Patient compliance
Patients
Population
Quality of life
Risk factors
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Summary:Patients with head and neck cancer (HNC) often experience cognitive impairment. However, the relationship between cancer and Alzheimer's disease (AD) remains unclear. We aimed to elucidate the relationship between patients with HNC and their subsequent AD development. This retrospective study used data from a nationwide representative cohort sample, the Korean National Health Insurance Service Cohort. The cancer group was defined based on the presence of diagnostic codes for HNC (C00-C14 and C30-C32). After matching the independent variables with a propensity score of 4:1, a total of 2304 people without HNC and 576 with HNC were enrolled in this study. Hazard ratios (HRs) of AD incidence (per 1000 person-years) and 95% confidence intervals (CIs) in HNC patients were calculated. The incidence of AD was 14.92 in HNC patients and 9.77 in non-cancer patients. Additionally, the HNC group was found to have a higher risk of developing AD compared with the non-cancer group. Female and middle-aged HNC patients had a higher risk of developing AD events compared with other subgroups. Surprisingly, during the observation period, the risk of developing AD was relatively high within the first year after HNC diagnosis. In conclusion, our study suggests that HNC and AD are positively correlated.
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers15235516