The role of sex hormones and receptors in HBV infection and development of HBV‐related HCC

Gender disparity in hepatitis B virus (HBV)‐related diseases has been extensively documented. Epidemiological studies consistently reported that males have a higher prevalence of HBV infection and incidence of hepatocellular carcinoma (HCC). Further investigations have revealed that sex hormone‐rela...

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Bibliographic Details
Published in:Journal of medical virology 2023-12, Vol.95 (12), p.e29298-n/a
Main Authors: Nuermaimaiti, Abudulimutailipu, Chang, Le, Yan, Ying, Sun, Huizhen, Xiao, Yingzi, Song, Shi, Feng, Kaihao, Lu, Zhuoqun, Ji, Huimin, Wang, Lunan
Format: Article
Language:English
Subjects:
androgen receptor
Antitumor activity
Carcinoma, Hepatocellular
Epidemiology
estrogen receptor α
Gender
Gonadal Steroid Hormones
Health services
Hepatitis B
Hepatitis B - complications
Hepatitis B - epidemiology
Hepatitis B virus
Hepatitis B, Chronic - complications
Hepatocellular carcinoma
hormone therapy
Hormones
Humans
Immune response
Liver cancer
Liver Neoplasms - epidemiology
Male
Sex hormones
Virology
Viruses
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Summary:Gender disparity in hepatitis B virus (HBV)‐related diseases has been extensively documented. Epidemiological studies consistently reported that males have a higher prevalence of HBV infection and incidence of hepatocellular carcinoma (HCC). Further investigations have revealed that sex hormone‐related signal transductions play a significant role in gender disparity. Sex hormone axes showed significantly different responses to virus entry and replication. The sex hormones axes change the HBV‐specific immune responses and antitumor immunity. Additionally, Sex hormone axes showed different effects on the development of HBV‐related disease. But the role of sex hormones remains controversial, and researchers have not reached a consensus on the role of sex hormones and the use of hormone therapies in HCC treatment. In this review, we aim to summarize the experimental findings on sex hormones and provide a comprehensive understanding of their roles in the development of HCC and their implications for hormone‐related HCC treatment.
ISSN:0146-6615
1096-9071
DOI:10.1002/jmv.29298