The Impact of Alcohol Consumption Pattern on Liver Fibrosis in Asymptomatic Patients

Alcohol consumption (AC) represents a widespread cause of liver diseases affecting 10-20% of the population. The study aimed to evaluate the relationship between advanced liver fibrosis (ALF) measured by transient elastography (TE), laboratory parameters, and the amount of AC depending on non-modifi...

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Bibliographic Details
Published in:Journal of clinical medicine 2023-11, Vol.12 (23), p.7405
Main Authors: Minea, Horia, Singeap, Ana-Maria, Sfarti, Catalin Victor, Girleanu, Irina, Chiriac, Stefan, Muzica, Cristina, Cuciureanu, Tudor, Petrea, Oana Cristina, Huiban, Laura, Zenovia, Sebastian, Nastasa, Robert, Rotaru, Adrian, Stafie, Remus, Stratina, Ermina, Cojocariu, Camelia, Stanciu, Carol, Trifan, Anca
Format: Article
Language:English
Subjects:
Alcohol
Asymptomatic
Beer
Beverages
Biomarkers
Cholesterol
Clinical medicine
Diagnosis
Drinking of alcoholic beverages
Enzymes
Females
Fibrosis
Gender
Health aspects
Liquor
Liver cancer
Liver cirrhosis
Liver diseases
Males
Mortality
Patients
Risk factors
Triglycerides
Womens health
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Summary:Alcohol consumption (AC) represents a widespread cause of liver diseases affecting 10-20% of the population. The study aimed to evaluate the relationship between advanced liver fibrosis (ALF) measured by transient elastography (TE), laboratory parameters, and the amount of AC depending on non-modifiable risk factors such as age and gender. We examined 689 patients with an average age of 49.32 ± 14.31 years, 72.9% males, without liver pathology, who admitted a moderate/high consumption (female ≤ 7 versus > 7 drinks/week; male ≤ 14 versus > 14 drinks/week) for at least five years. The fibrosis level was adjusted according to transaminase levels. Predictive factors were established using univariate regression analysis. ALF (≥F3) was detected in 19.30% of subjects, predominantly males (14.1%) and patients over 55 years (12.5%). Excessive consumption of distilled spirits is associated with ALF in females (OR = 4.5), males (OR = 6.43) and patients over 55 years (OR = 3.73). A particularity highlighted in both genders, regardless of the age group, was the negative correlation between the decrease in the number of platelets, the albumin concentration, and the appearance of AFL. Screening using TE represents an approach for early detection of ALF in asymptomatic populations and the development of a risk stratification scheme.
ISSN:2077-0383
2077-0383
DOI:10.3390/jcm12237405