Advances in cellular resolution microscopy for brain imaging in rats

Rats are used in neuroscience research because of their physiological similarities with humans and accessibility as model organisms, trainability, and behavioral repertoire. In particular, rats perform a wide range of sophisticated social, cognitive, motor, and learning behaviors within the contexts...

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Bibliographic Details
Published in:Neurophotonics (Print) 2023-10, Vol.10 (4), p.044304
Main Authors: Kim, Su Jin, Affan, Rifqi O, Frostig, Hadas, Scott, Benjamin B, Alexander, Andrew S
Format: Article
Language:English
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Summary:Rats are used in neuroscience research because of their physiological similarities with humans and accessibility as model organisms, trainability, and behavioral repertoire. In particular, rats perform a wide range of sophisticated social, cognitive, motor, and learning behaviors within the contexts of both naturalistic and laboratory environments. Further progress in neuroscience can be facilitated by using advanced imaging methods to measure the complex neural and physiological processes during behavior in rats. However, compared with the mouse, the rat nervous system offers a set of challenges, such as larger brain size, decreased neuron density, and difficulty with head restraint. Here, we review recent advances in imaging techniques in rats with a special focus on open-source solutions for calcium imaging. Finally, we provide suggestions for both users and developers of imaging systems for rats.
ISSN:2329-423X
DOI:10.1117/1.NPh.10.4.044304