Unlocking the EGFR-mediated epitranscriptome: A pathway to novel therapies

In this issue, Lv et al. explore EGFR-driven epitranscriptomic reprogramming in glioblastoma, revealing the pivotal role of the EGFR-ALKBH5-GCLM axis in ferroptosis protection. Their findings offer mechanistic insight and therapeutic strategies involving novel combination targets to enhance tumor re...

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Bibliographic Details
Published in:Molecular cell 2023-12, Vol.83 (23), p.4199-4201
Main Authors: Gencel-Augusto, Jovanka, Bivona, Trever G
Format: Article
Language:English
Subjects:
Brain Neoplasms - genetics
Brain Neoplasms - pathology
ErbB Receptors - genetics
ErbB Receptors - metabolism
Glioblastoma - genetics
Glioblastoma - metabolism
Humans
Citations: Items that this one cites
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Summary:In this issue, Lv et al. explore EGFR-driven epitranscriptomic reprogramming in glioblastoma, revealing the pivotal role of the EGFR-ALKBH5-GCLM axis in ferroptosis protection. Their findings offer mechanistic insight and therapeutic strategies involving novel combination targets to enhance tumor responses.
ISSN:1097-2765
1097-4164
DOI:10.1016/j.molcel.2023.10.044