Proteases of Acanthamoeba

The members of genus Acanthamoeba are the etiological agent of uncommon but severe or even fatal opportunistic infections in human beings. The presence of different classes of intracellular and extracellular proteases including serine proteases, cysteine proteases, and metalloproteases has been well...

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Bibliographic Details
Published in:Parasitology research (1987) 2024-01, Vol.123 (1), p.19-19, Article 19
Main Authors: Mahdavi Poor, Behroz, Rashedi, Jalil, Asgharzadeh, Vahid, Mirmazhary, Amirali, Gheitarani, Nazila
Format: Article
Language:English
Subjects:
Acanthamoeba
Acanthamoeba Keratitis
Amoeba
Aspartic proteinases
Biomedical and Life Sciences
Biomedicine
Cell Line
Cell lines
Clinical isolates
Cysteine
Enzymes
Health aspects
Humans
Immunology
Infection
Intracellular
Medical Microbiology
Microbiology
Pathogenicity
Physiological aspects
Proteolysis
Proteolytic enzymes
Review
Serine Endopeptidases
Serine Proteases - metabolism
Serine proteinase
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Summary:The members of genus Acanthamoeba are the etiological agent of uncommon but severe or even fatal opportunistic infections in human beings. The presence of different classes of intracellular and extracellular proteases including serine proteases, cysteine proteases, and metalloproteases has been well documented in environmental and clinical isolates of Acanthamoeba spp. However, the role of the proteolytic enzymes in physiological, biological, and pathological mechanisms of the amoeba remains partially investigated. Some attempts have been conducted using various methods to determine the profile of proteases (number, class, optimal conditions, and activity of the enzymes), and possible pathogenicity mechanism of the proteolytic enzymes (various protein substrate degradation, cytopathic effect on different cell lines). In some cases, it was attempted to correlate intracellular and extracellular protease profile with pathogenicity potential of strains. This review revealed that the protease profile of different strains of Acanthamoeba was extremely complex, therefore, further comprehensive studies with application of a combination of various methods may help to elucidate the role of the enzymes.
ISSN:0932-0113
1432-1955
DOI:10.1007/s00436-023-08059-z