Effects of N‐acetyl‐L‐cysteine against apical periodontitis in rats with adriamycin‐induced cardiomyopathy and nephropathy

Aim This study aimed to investigate the potential protective effects of N‐acetyl‐L‐cysteine (NAC) against apical periodontitis (AP) in rats with adriamycin (ADR)‐induced kidney and heart diseases. Methodology Fourty‐eight Wistar albino rats were divided into six groups: (1) Control group, (2) ADR gr...

Full description

Saved in:
Bibliographic Details
Published in:International endodontic journal 2024-02, Vol.57 (2), p.195-207
Main Authors: Şehirli, Ahmet Özer, Aksoy, Umut, Sibai, Abdullah, Orhan, Kaan, Sayıner, Serkan
Format: Article
Language:English
Subjects:
Acetylcysteine
Acetylcysteine - pharmacology
Acetylcysteine - therapeutic use
adriamycin
animal model
Animals
apical periodontitis
Body Weight
Bone resorption
Cardiomyopathies - chemically induced
Cardiomyopathies - drug therapy
Cardiomyopathy
Creatinine
Cysteine
cytokines
Dental caries
Doxorubicin
Gum disease
Heart
Heart diseases
Inflammation
Jaw
Kidneys
Nephropathy
n‐acetyl‐L‐cysteine
Periapical Periodontitis - chemically induced
Periapical Periodontitis - drug therapy
Periodontitis
Rats
Rats, Wistar
Serum levels
Statistical analysis
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Aim This study aimed to investigate the potential protective effects of N‐acetyl‐L‐cysteine (NAC) against apical periodontitis (AP) in rats with adriamycin (ADR)‐induced kidney and heart diseases. Methodology Fourty‐eight Wistar albino rats were divided into six groups: (1) Control group, (2) ADR group (1 mg/kg/day ip for 10 days), (3) AP Group (1st mandibular molar tooth), (4) AP + ADR Group, (5) AP + NAC group (150 mg/kg/day ip), and (6) AP + ADR + NAC group. After 3 weeks, the rats were decapitated and blood and tissue samples (heart, kidney, and jaw) were collected. Tissue samples were evaluated by biochemical (inflammatory cytokines and hemodynamic parameters) and radiological analyses. One‐way anova with Tukey post hoc tests was used to compare data, considering p 
ISSN:0143-2885
1365-2591
DOI:10.1111/iej.14010