Evaluation of the stability of aciclovir in elastomeric infusion devices used for outpatient parenteral antimicrobial therapy

ObjectivesTo investigate the stability of aciclovir solutions in elastomeric devices used for outpatient parenteral antimicrobial therapy (OPAT).MethodsTriplicates of two elastomeric devices, Accufuser and Easypump II, were filled with a solution of 200 mg, 2400 mg, and 4500 mg aciclovir in 240 mL 0...

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Bibliographic Details
Published in:European journal of hospital pharmacy. Science and practice 2023-12, p.ejhpharm-2023-003784
Main Authors: Sime, Fekade Bruck, Wallis, Steven, Jamieson, Conor, Hills, Tim, Gilchrist, Mark, Santillo, Mark, Seaton, R Andrew, Drummond, Felicity, Roberts, Jason
Format: Article
Language:English
Subjects:
Antimicrobial agents
Encephalitis
Infections
Original research
Patients
Pharmaceuticals
Precipitation
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Summary:ObjectivesTo investigate the stability of aciclovir solutions in elastomeric devices used for outpatient parenteral antimicrobial therapy (OPAT).MethodsTriplicates of two elastomeric devices, Accufuser and Easypump II, were filled with a solution of 200 mg, 2400 mg, and 4500 mg aciclovir in 240 mL 0.9% w/v saline. Devices were stored at room temperature for 14 days, followed by 24 hours storage at 32°C. Assessment using a stability indicating assay, pH and subvisible particle analysis was undertaken at 11 time points throughout the study.ResultsAciclovir solution at 200 mg and 2400 mg in 240 mL was stable for 14 days at room temperature (
ISSN:2047-9956
2047-9964
DOI:10.1136/ejhpharm-2023-003784