Spatial Dynamic Subspaces Encode Sex-Specific Schizophrenia Disruptions in Transient Network Overlap and Their Links to Genetic Risk

• Published in: Biological psychiatry (1969) 2024-08, Vol.96 (3), p.188-197
• Main Authors: Iraji, Armin, Chen, Jiayu, Lewis, Noah, Faghiri, Ashkan, Fu, Zening, Agcaoglu, Oktay, Kochunov, Peter, Adhikari, Bhim M., Mathalon, Daniel H., Pearlson, Godfrey D., Macciardi, Fabio, Preda, Adrian, van Erp, Theo G.M., Bustillo, Juan R., Díaz-Caneja, Covadonga M., Andrés-Camazón, Pablo, Dhamala, Mukesh, Adali, Tulay, Calhoun, Vince D.
• Format: Article
• Language: English
• Subjects: Adult; Brain - diagnostic imaging; Brain - physiopathology; Connectome; Female; Genetic Predisposition to Disease - genetics; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Nerve Net - diagnostic imaging; Nerve Net - physiopathology; Neural Pathways - diagnostic imaging; Neural Pathways - physiopathology; Polygenic risk score; Schizophrenia (SZ); Schizophrenia - diagnostic imaging; Schizophrenia - genetics; Schizophrenia - physiopathology; Sex Characteristics; Sex differences; Single nucleotide polymorphism (SNP); Spatial dynamics; Spatially dynamic covariance; Young Adult
• ISSN: 0006-3223; 1873-2402; 1873-2402
• DOI: 10.1016/j.biopsych.2023.12.002

Schizophrenia research reveals sex differences in incidence, symptoms, genetic risk factors, and brain function. However, a knowledge gap remains regarding sex-specific schizophrenia alterations in brain function. Schizophrenia is considered a dysconnectivity syndrome, but the dynamic integration and segregation of brain networks are poorly understood. Recent advances in resting-state functional magnetic resonance imaging allow us to study spatial dynamics, the phenomenon of brain networks spatially evolving over time. Nevertheless, estimating time-resolved networks remains challenging due to low signal-to-noise ratio, limited short-time information, and uncertain network identification. We adapted a reference-informed network estimation technique to capture time-resolved networks and their dynamic spatial integration and segregation for 193 individuals with schizophrenia and 315 control participants. We focused on time-resolved spatial functional network connectivity, an estimate of network spatial coupling, to study sex-specific alterations in schizophrenia and their links to genomic data. Our findings are consistent with the dysconnectivity and neurodevelopment hypotheses and with the cerebello-thalamo-cortical, triple-network, and frontoparietal dysconnectivity models, helping to unify them. The potential unification offers a new understanding of the underlying mechanisms. Notably, the posterior default mode/salience spatial functional network connectivity exhibits sex-specific schizophrenia alteration during the state with the highest global network integration and is correlated with genetic risk for schizophrenia. This dysfunction is reflected in regions with weak functional connectivity to corresponding networks. Our method can effectively capture spatially dynamic networks, detect nuanced schizophrenia effects including sex-specific ones, and reveal the intricate relationship of dynamic information to genomic data. The results also underscore the clinical potential of dynamic spatial dependence and weak connectivity.