Emergence of OXA-48-producing hypervirulent Klebsiella pneumoniae strains in Taiwan

The OXA-48-producing hypervirulent Klebsiella pneumoniae (hvKP) strains were rarely reported. In this study, we characterized three carbapenem-resistant hvKP strains (KP2185, NCRE61, and KP2683-1) isolated from renal abscess, scrotal abscess, and blood samples in a Taiwan hospital. The three strains...

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Bibliographic Details
Published in:European journal of clinical microbiology & infectious diseases 2024-02, Vol.43 (2), p.389-393
Main Authors: Lin, Yi-Tsung, Chuang, Chien, Chou, Sheng-Hua, Juan, Chih-Han, Yang, Tsuey-Ching, Kreiswirth, Barry N., Chen, Liang
Format: Article
Language:English
Subjects:
Abscesses
Antimicrobial agents
Biomedical and Life Sciences
Biomedicine
Brief Report
Carbapenems
Catheters
Gene sequencing
Genes
Genomes
Hospitals
Infectious diseases
Internal Medicine
Klebsiella
Klebsiella pneumoniae
Laboratories
Medical Microbiology
Medicine
Microbiology
Mortality
Nosocomial infections
Ostomy
Plasmids
Virulence
Whole genome sequencing
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Summary:The OXA-48-producing hypervirulent Klebsiella pneumoniae (hvKP) strains were rarely reported. In this study, we characterized three carbapenem-resistant hvKP strains (KP2185, NCRE61, and KP2683-1) isolated from renal abscess, scrotal abscess, and blood samples in a Taiwan hospital. The three strains belonged to two different clones: ST23 K1 (KP2683-1) and ST11 KL64 (KP2185 and NCRE61). KP2683-1 exhibited the highest virulence in an in vivo model. Whole-genome sequencing analysis showed that KP2185 and NCRE61 acquired IncFIB type plasmids containing a set of virulence genes ( iroBCDN , iucABCD , rmpA , rmpA2 , and iutA ), while KP2683-1 acquired an IncL type plasmid harboring bla OXA-48 .
ISSN:0934-9723
1435-4373
DOI:10.1007/s10096-023-04733-3