Characteristic patterns of functional connectivity-mediated cerebral small vessel disease-related cognitive impairment and depression

Abstract Cerebral small vessel disease is common in most individuals aged 60 years or older, and it is associated with cognitive dysfunction, depression, anxiety disorder, and mobility problems. Currently, many cerebral small vessel disease patients have both cognitive impairment and depressive symp...

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Published in:Cerebral cortex (New York, N.Y. 1991) N.Y. 1991), 2024-01, Vol.34 (1)
Main Authors: Xu, Jingxian, Chen, Haifeng, Hu, Zheqi, Ke, Zhihong, Qin, Ruomeng, Chen, Ying, Xu, Yun
Format: Article
Language:English
Subjects:
Brain - diagnostic imaging
Cerebral Small Vessel Diseases - complications
Cerebral Small Vessel Diseases - diagnostic imaging
Cognitive Dysfunction - diagnostic imaging
Cognitive Dysfunction - etiology
Depression - diagnostic imaging
Humans
Magnetic Resonance Imaging
White Matter - diagnostic imaging
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Summary:Abstract Cerebral small vessel disease is common in most individuals aged 60 years or older, and it is associated with cognitive dysfunction, depression, anxiety disorder, and mobility problems. Currently, many cerebral small vessel disease patients have both cognitive impairment and depressive symptoms, but the relationship between the 2 is unclear. The present research combined static and dynamic functional network connectivity methods to explore the patterns of functional networks in cerebral small vessel disease individuals with cognitive impairment and depression (cerebral small vessel disease–mild cognitive impairment with depression) and their relationship. We found specific functional network patterns in the cerebral small vessel disease–mild cognitive impairment with depression individuals (P 
ISSN:1047-3211
1460-2199
DOI:10.1093/cercor/bhad468