Agaricus blazei Polysaccharide Alleviates DSS-Induced Colitis in Mice by Modulating Intestinal Barrier and Remodeling Metabolism

Ulcerative colitis (UC) is a chronic noninfectious intestinal disease that severely affects patients' quality of life. Murrill polysaccharide (ABP) is an effective active ingredient extracted from Murrill (ABM). It has good efficacy in inhibiting tumor cell growth, lowering blood pressure, and...

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Published in:Nutrients 2023-11, Vol.15 (23), p.4877
Main Authors: Ji, Zhong-Hao, He, Song, Xie, Wen-Yin, Zhao, Pei-Sen, Ren, Wen-Zhi, Gao, Wei, Yuan, Bao
Format: Article
Language:English
Subjects:
Animal welfare
Animals
Antibodies
Bacteria
Biotechnology
Colitis - chemically induced
Colitis - drug therapy
Colitis, Ulcerative - chemically induced
Colitis, Ulcerative - drug therapy
Colon
Dextran Sulfate
Disease
Disease Models, Animal
Humans
Inflammatory bowel disease
Metabolism
Metabolites
Mice
Mice, Inbred C57BL
Microbiota
Noncommunicable Diseases
Polysaccharides - pharmacology
Quality of Life
RNA, Ribosomal, 16S
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Summary:Ulcerative colitis (UC) is a chronic noninfectious intestinal disease that severely affects patients' quality of life. Murrill polysaccharide (ABP) is an effective active ingredient extracted from Murrill (ABM). It has good efficacy in inhibiting tumor cell growth, lowering blood pressure, and improving atherosclerosis. However, its effect on colitis is unclear. The aim of this study was to analyze the protective effects and potential mechanisms of ABP against dextran sulfate sodium (DSS)-induced acute colitis in mice. The results showed that dietary supplementation with ABP significantly alleviated DSS-induced colitis symptoms, inflammatory responses, and oxidative stress. Meanwhile, ABP intervention was able to maintain the integrity of the intestinal mechanical barrier by promoting the expression of ZO-1 and Occludin tight junction proteins and facilitating mucus secretion. Moreover, 16S rRNA sequencing results suggested that ABP intervention was able to alleviate DSS-induced gut microbiota disruption, and nontargeted metabolomics results indicated that ABP was able to remodel metabolism. In conclusion, these results demonstrate that dietary supplementation with ABP alleviated DSS-induced acute colitis by maintaining intestinal barrier integrity and remodeling metabolism. These results improve our understanding of ABP function and provide a theoretical basis for the use of dietary supplementation with ABP for the prevention of ulcerative colitis.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu15234877