Hydrogels Loaded with Atorvastatin‐Metal Organic Framework Have a Preventive Effect on Coronary Heart Disease

• Published in: Chemistry & biodiversity 2024-02, Vol.21 (2), p.e202301511-n/a
• Main Authors: Bai, Xinghua, Jiang, Jun, Tu, Sijia, Zhang, Weizong
• Format: Article
• Language: English
• Subjects: Alginic acid; Atorvastatin; Atorvastatin - pharmacology; Calcium alginate; Cardiomyocytes; Cardiovascular diseases; Chemical composition; Chitosan; Coordination polymers; Copper; Coronary artery disease; Coronary Disease; coronary heart; Dimethyl sulfoxide; Fourier transforms; gel; Heart diseases; Humans; Hydrogels - pharmacology; Infrared analysis; Infrared spectroscopy; Metal-Organic Frameworks; Metals; Polymers; Raw materials; Scanning electron microscopy; Spectroscopy, Fourier Transform Infrared; Thermogravimetric analysis
• ISSN: 1612-1872; 1612-1880
• DOI: 10.1002/cbdv.202301511

In the research, a new three‐dimensional coordination polymer was synthesized by solvothermal method based on the metal ligand LCu=[Cu(2,4‐pydca)2]2− (2,4‐pydca=pyridine‐2,4‐dicarboxylate) and alkaline‐earth ion CaII with chemical composition {[Ca(H2O)2][LCu]⋅DMSO ⋅ 2H2O}n (1) (DMSO=dimethyl sulfoxide). The complex 1 was characterized soundly by Fourier transform infrared (FT‐IR) spectroscopy, elemental analysis (EA), single‐crystal X‐ray diffraction (SCXRD) and thermogravimetric analysis (TGA). Using atorvastatin as drug model, carboxymethyl chitosan and calcium alginate as raw materials, a new type of metal gel particles was prepared. The microstructure of the gel was observed by scanning Electron Microscope (SEM) and its modulation effect on the activity of human cardiomyocytes was evaluated. The results show that the gel particles presented a three‐dimensional porous structure and were able to significantly up‐regulate the cell activity of human cardiomyocytes, which is expected to develop the metal gel particles into drugs for the treatment of coronary heart disease.