Maternal dietary patterns and placental outcomes among pregnant women in Los Angeles

• Published in: Placenta (Eastbourne) 2024-01, Vol.145, p.72-79
• Main Authors: Meng, Qi, Del Rosario, Irish, Sung, Kyunghyun, Janzen, Carla, Devaskar, Sherin U, Carpenter, Catherine L, Ritz, Beate
• Format: Article
• Language: English
• Subjects: Animals; Diet; Dietary Patterns; Female; Humans; Infant, Newborn; Los Angeles - epidemiology; Male; Placenta - diagnostic imaging; Pregnancy; Pregnant Women
• ISSN: 0143-4004; 1532-3102; 1532-3102
• DOI: 10.1016/j.placenta.2023.12.002

Epidemiological studies have linked prenatal maternal diet to fetal growth, but whether diet affects placental outcomes is poorly understood. We collected past month dietary intake from 148 women in mid-pregnancy enrolled at University of California Los Angeles (UCLA) antenatal clinics from 2016 to 2019. We employed the food frequency Diet History Questionnaire II and generated the Healthy Eating Index-2015 (HEI-2015), the Alternate Healthy Eating Index for Pregnancy (AHEI-P), and the Alternate Mediterranean Diet (aMED). We conducted T -weighted magnetic resonance imaging (MRI) in mid-pregnancy (1st during 14-17 and 2nd during 19-24 gestational weeks) to evaluate placental volume (cm ) and we measured placenta weight (g) at delivery. We estimated change and 95 % confidence interval (CI) in placental volume and associations of placenta weight with all dietary index scores and diet items using linear regression models. Placental volume in mid-pregnancy was associated with an 18.9 cm (95 % CI 5.1, 32.8) increase per 100 gestational days in women with a higher HEI-2015 (≥median), with stronger results for placentas of male fetuses. We estimated positive associations between placental volume at the 1st and 2nd MRI and higher intake of vegetables, high-fat fish, dairy, and dietary intake of B vitamins. A higher aMED (≥median) score was associated with a 40.5 g (95 % CI 8.5, 72.5) increase in placenta weight at delivery, which was mainly related to protein intake. Placental growth represented by volume in mid-pregnancy and weight at birth is influenced by the quality and content of the maternal diet.