Cytogenetics in the management of B-cell acute lymphoblastic leukemia: Guidelines from the Groupe Francophone de Cytogénétique Hématologique (GFCH)

Cytogenetic analysis is mandatory at initial assessment of B-cell acute lymphoblastic leukemia (B-ALL) due to its diagnostic and prognostic value. Results from chromosome banding analysis and complementary FISH are taken into account in therapeutic protocols and further completed by other techniques...

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Bibliographic Details
Published in:Current research in translational medicine 2023-10, Vol.71 (4), p.103434-103434, Article 103434
Main Authors: Tueur, Giulia, Quessada, Julie, De Bie, Jolien, Cuccuini, Wendy, Toujani, Saloua, Lefebvre, Christine, Luquet, Isabelle, Michaux, Lucienne, Lafage-Pochitaloff, Marina
Format: Article
Language:English
Subjects:
B-cell acute lymphoblastic leukemia
Cytogenetic Analysis - methods
Cytogenetics
Cytogenomics
Hematology
Humans
ICC classification
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Prognosis
Societies, Medical
WHO classification
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Summary:Cytogenetic analysis is mandatory at initial assessment of B-cell acute lymphoblastic leukemia (B-ALL) due to its diagnostic and prognostic value. Results from chromosome banding analysis and complementary FISH are taken into account in therapeutic protocols and further completed by other techniques (RT-PCR, SNP-array, MLPA, NGS, OGM). Indeed, new genomic entities have been identified by NGS, mostly RNA sequencing, such as Ph-like ALL that can benefit from targeted therapy. Here, we have attempted to establish cytogenetic guidelines by reviewing the most recent published data including the novel 5th World Health Organization and International Consensus Classifications. We also focused on newly described cytogenomic entities and indicate alternative diagnostic tools such as NGS technology, as its importance is vastly increasing in the diagnostic setting.
ISSN:2452-3186
2452-3186
DOI:10.1016/j.retram.2023.103434