Embryonal and pineal tumours

Embryonal and pineal tumours represent a diverse group of central nervous system (CNS) neoplasms. While many of the small round blue cell tumours that make up the embryonal neoplasms share similar histologic qualities, there are several morphologic and cytologic characteristics that are useful in di...

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Bibliographic Details
Published in:Cytopathology (Oxford) 2024-09, Vol.35 (5), p.561-571
Main Authors: Reznicek, Joseph, Sharifai, Nima, Jamshidi, Pouya, Wadhwani, Nitin, Ahrendsen, Jared T
Format: Article
Language:English
Subjects:
Brain architecture
Brain Neoplasms - diagnosis
Brain Neoplasms - genetics
Brain Neoplasms - pathology
Brain tumors
Central nervous system
Humans
Neoplasms, Germ Cell and Embryonal - diagnosis
Neoplasms, Germ Cell and Embryonal - pathology
Pineal gland
Pineal Gland - pathology
Pinealoma - diagnosis
Pinealoma - pathology
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Summary:Embryonal and pineal tumours represent a diverse group of central nervous system (CNS) neoplasms. While many of the small round blue cell tumours that make up the embryonal neoplasms share similar histologic qualities, there are several morphologic and cytologic characteristics that are useful in distinguishing different tumour types. Similarly, pineal parenchymal tumours represent clinically diverse tumours, ranging from benign to overtly malignant. The most recent iteration of the World Health Organization Classification of CNS Tumours expanded greatly on the significance of molecular alterations in brain tumour diagnostics. In this article, we summarize the salient cytologic and histologic features of CNS embryonal and pineal tumours, and highlight diagnostically relevant molecular alterations within each tumour type.
ISSN:0956-5507
1365-2303
1365-2303
DOI:10.1111/cyt.13350