Serine metabolism in macrophage polarization

Objective Emerging studies have revealed that macrophages possess different dependences on the uptake, synthesis, and metabolism of serine for their activation and functionalization, necessitating our insight into how serine availability and utilization impact macrophage activation and inflammatory...

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Bibliographic Details
Published in:Inflammation research 2024, Vol.73 (1), p.83-98
Main Authors: Huang, Xinqiong, Yang, Xue, Xiang, Li, Chen, Yuping
Format: Article
Language:English
Subjects:
Allergology
Biomedical and Life Sciences
Biomedicine
Cell activation
Dermatology
Epigenetics
Immunology
Inflammatory diseases
Macrophages
Metabolic flux
Metabolic pathways
Metabolism
Neurology
Pharmacology/Toxicology
Polarization
Post-translation
Review
Rheumatology
Serine
Synthesis
Therapeutic targets
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Summary:Objective Emerging studies have revealed that macrophages possess different dependences on the uptake, synthesis, and metabolism of serine for their activation and functionalization, necessitating our insight into how serine availability and utilization impact macrophage activation and inflammatory responses. Methods This article summarizes the reports published domestically and internationally about the serine uptake, synthesis, and metabolic flux by the macrophages polarizing with distinct stimuli and under different pathologic conditions, and particularly analyzes how altered serine metabolism rewires the metabolic behaviors of polarizing macrophages and their genetic and epigenetic reprogramming. Results Macrophages dynamically change serine metabolism to orchestrate their anabolism, redox balance, mitochondrial function, epigenetics, and post-translation modification, and thus match the distinct needs for both classical and alternative activation. Conclusion Serine metabolism coordinates multiple metabolic pathways to tailor macrophage polarization and their responses to different pathogenic attacks and thus holds the potential as therapeutic target for types of acute and chronic inflammatory diseases.
ISSN:1023-3830
1420-908X
DOI:10.1007/s00011-023-01815-y