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Renal Dysfunction in Primary Hyperparathyroidism is associated with nephrolithiasis, elevated serum calcium-phosphate product and parathormone levels
Purpose Baseline renal dysfunction predicts mortality in primary hyperparathyroidism (PHPT). However, it remains controversial whether renal insufficiency in PHPT is due to disease severity alone or other risk factors. This study aimed to explore the association of clinico-biochemical variables with...
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| Published in: | Endocrine 2024-03, Vol.83 (3), p.757-762 |
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| container_end_page | 762 |
| container_issue | 3 |
| container_start_page | 757 |
| container_title | Endocrine |
| container_volume | 83 |
| creator | Banerjee, Mainak Kar, Anish Ahamed, Jan Bhattacharjee, Rana Maitra, Dhritiman Maisnam, Indira Das, Tapas Chandra Sahana, Pranab Kumar Chowdhury, Subhankar Mukhopadhyay, Satinath |
| description | Purpose
Baseline renal dysfunction predicts mortality in primary hyperparathyroidism (PHPT). However, it remains controversial whether renal insufficiency in PHPT is due to disease severity alone or other risk factors. This study aimed to explore the association of clinico-biochemical variables with renal dysfunction [estimated glomerular filtration rate (eGFR) |
| doi_str_mv | 10.1007/s12020-023-03631-0 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2902973480</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2933027689</sourcerecordid><originalsourceid>FETCH-LOGICAL-c326t-c73b4e4ee914128535166653b3f2624c9442a50d5700575531e6c8488987ea7f3</originalsourceid><addsrcrecordid>eNp9kcFu1TAQRS0EoqXwAyyQJTYsSBnbcZwsUQsUqRIIwdrycybEVRIHTwJ6H9L_rV9ToGLBaka6Z-6M5jL2XMCpADBvSEiQUIBUBahKiQIesGOhdVNA1h_e64_YE6IrACllZR6zI1VDI0RTH7PrLzi5gZ_vqVsnv4Q48TDxzymMLu35xX7GNLvkln6fYmgDjTwQd0TRB7dgy3-FpecTzn2KQ26Do0CvOQ7481YmTOvIvRt8WMdi7iPNfRb4nGK7-oW7qeWbf0xjnJDnQRzoKXvUuYHw2V09Yd_ev_t6dlFcfvrw8eztZeGVrJbCG7UrsURsRClkrZUWVVVptVOdrGTpm7KUTkOrDYA2WiuBla_Lum5qg8506oS92nzzPT9WpMWOgTwOg5swrmRlA7Ixqqwhoy__Qa_imvLvDpRSIE1VN5mSG-VTJErY2Xl7pRVgD6HZLTSbQ7O3odmD9Ys763U3Yvtn5HdKGVAbQFmavmP6u_s_tjc8IKQG</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2933027689</pqid></control><display><type>article</type><title>Renal Dysfunction in Primary Hyperparathyroidism is associated with nephrolithiasis, elevated serum calcium-phosphate product and parathormone levels</title><source>Springer Link</source><creator>Banerjee, Mainak ; Kar, Anish ; Ahamed, Jan ; Bhattacharjee, Rana ; Maitra, Dhritiman ; Maisnam, Indira ; Das, Tapas Chandra ; Sahana, Pranab Kumar ; Chowdhury, Subhankar ; Mukhopadhyay, Satinath</creator><creatorcontrib>Banerjee, Mainak ; Kar, Anish ; Ahamed, Jan ; Bhattacharjee, Rana ; Maitra, Dhritiman ; Maisnam, Indira ; Das, Tapas Chandra ; Sahana, Pranab Kumar ; Chowdhury, Subhankar ; Mukhopadhyay, Satinath</creatorcontrib><description><![CDATA[Purpose
Baseline renal dysfunction predicts mortality in primary hyperparathyroidism (PHPT). However, it remains controversial whether renal insufficiency in PHPT is due to disease severity alone or other risk factors. This study aimed to explore the association of clinico-biochemical variables with renal dysfunction [estimated glomerular filtration rate (eGFR) < 60 ml/min/m
2
] in PHPT.
Methods
A total of 112 patients of PHPT were selected and divided into following subgroups: renal dysfunction (n = 28) and normal renal function (n = 84). Demographic characteristics, traditional risk factors, phenotypes of PHPT based on target organ involvement, and biochemical parameters were compared between these subgroups.
Results
Patient subgroups of PHPT with and without renal dysfunction had similar age, frequency of diabetes, and hypertension. Renal dysfunction was more prevalent in males (p < 0.05). Compared to normal renal function subgroup, individuals with renal dysfunction had higher serum levels of calcium, phosphate, alkaline phosphatase, intact parathormone (all p < 0.05), while having lower hemoglobin levels (p < 0.05) and higher nephrolithiasis rates (p < 0.05). Multiple regression analysis revealed that nephrolithiasis, serum calcium-phosphorous product (CaxP), parathormone levels were positively associated with baseline renal dysfunction (all p < 0.01). A baseline PTH > 456 pg/mL and CaxP > 30.0 mg
2
/dl
2
could discriminate renal dysfunction from normal renal function with sensitivity and specificity of 75% and 74.5% and 92.6% and 74.4%, respectively.
Conclusion
Renal dysfunction was associated with presence of nephrolithiasis, elevated serum CaxP and PTH levels in our cohort with predominantly symptomatic PHPT, indicating an association with the underlying disease itself. Serum CaxP may additionally be appraised during risk assessment in PHPT.]]></description><identifier>ISSN: 1559-0100</identifier><identifier>ISSN: 1355-008X</identifier><identifier>EISSN: 1559-0100</identifier><identifier>DOI: 10.1007/s12020-023-03631-0</identifier><identifier>PMID: 38091198</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Alkaline phosphatase ; Calcium (blood) ; Calcium phosphates ; Diabetes ; Diabetes mellitus ; Endocrinology ; Glomerular filtration rate ; Hemoglobin ; Humanities and Social Sciences ; Hyperparathyroidism ; Internal Medicine ; Kidney stones ; Medicine ; Medicine & Public Health ; multidisciplinary ; Multiple regression analysis ; Nephrolithiasis ; Original Article ; Parathyroid hormone ; Phenotypes ; Renal function ; Renal insufficiency ; Risk assessment ; Risk factors ; Science ; Serum levels</subject><ispartof>Endocrine, 2024-03, Vol.83 (3), p.757-762</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c326t-c73b4e4ee914128535166653b3f2624c9442a50d5700575531e6c8488987ea7f3</cites><orcidid>0000-0001-8033-5748</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38091198$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Banerjee, Mainak</creatorcontrib><creatorcontrib>Kar, Anish</creatorcontrib><creatorcontrib>Ahamed, Jan</creatorcontrib><creatorcontrib>Bhattacharjee, Rana</creatorcontrib><creatorcontrib>Maitra, Dhritiman</creatorcontrib><creatorcontrib>Maisnam, Indira</creatorcontrib><creatorcontrib>Das, Tapas Chandra</creatorcontrib><creatorcontrib>Sahana, Pranab Kumar</creatorcontrib><creatorcontrib>Chowdhury, Subhankar</creatorcontrib><creatorcontrib>Mukhopadhyay, Satinath</creatorcontrib><title>Renal Dysfunction in Primary Hyperparathyroidism is associated with nephrolithiasis, elevated serum calcium-phosphate product and parathormone levels</title><title>Endocrine</title><addtitle>Endocrine</addtitle><addtitle>Endocrine</addtitle><description><![CDATA[Purpose
Baseline renal dysfunction predicts mortality in primary hyperparathyroidism (PHPT). However, it remains controversial whether renal insufficiency in PHPT is due to disease severity alone or other risk factors. This study aimed to explore the association of clinico-biochemical variables with renal dysfunction [estimated glomerular filtration rate (eGFR) < 60 ml/min/m
2
] in PHPT.
Methods
A total of 112 patients of PHPT were selected and divided into following subgroups: renal dysfunction (n = 28) and normal renal function (n = 84). Demographic characteristics, traditional risk factors, phenotypes of PHPT based on target organ involvement, and biochemical parameters were compared between these subgroups.
Results
Patient subgroups of PHPT with and without renal dysfunction had similar age, frequency of diabetes, and hypertension. Renal dysfunction was more prevalent in males (p < 0.05). Compared to normal renal function subgroup, individuals with renal dysfunction had higher serum levels of calcium, phosphate, alkaline phosphatase, intact parathormone (all p < 0.05), while having lower hemoglobin levels (p < 0.05) and higher nephrolithiasis rates (p < 0.05). Multiple regression analysis revealed that nephrolithiasis, serum calcium-phosphorous product (CaxP), parathormone levels were positively associated with baseline renal dysfunction (all p < 0.01). A baseline PTH > 456 pg/mL and CaxP > 30.0 mg
2
/dl
2
could discriminate renal dysfunction from normal renal function with sensitivity and specificity of 75% and 74.5% and 92.6% and 74.4%, respectively.
Conclusion
Renal dysfunction was associated with presence of nephrolithiasis, elevated serum CaxP and PTH levels in our cohort with predominantly symptomatic PHPT, indicating an association with the underlying disease itself. Serum CaxP may additionally be appraised during risk assessment in PHPT.]]></description><subject>Alkaline phosphatase</subject><subject>Calcium (blood)</subject><subject>Calcium phosphates</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Endocrinology</subject><subject>Glomerular filtration rate</subject><subject>Hemoglobin</subject><subject>Humanities and Social Sciences</subject><subject>Hyperparathyroidism</subject><subject>Internal Medicine</subject><subject>Kidney stones</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>multidisciplinary</subject><subject>Multiple regression analysis</subject><subject>Nephrolithiasis</subject><subject>Original Article</subject><subject>Parathyroid hormone</subject><subject>Phenotypes</subject><subject>Renal function</subject><subject>Renal insufficiency</subject><subject>Risk assessment</subject><subject>Risk factors</subject><subject>Science</subject><subject>Serum levels</subject><issn>1559-0100</issn><issn>1355-008X</issn><issn>1559-0100</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kcFu1TAQRS0EoqXwAyyQJTYsSBnbcZwsUQsUqRIIwdrycybEVRIHTwJ6H9L_rV9ToGLBaka6Z-6M5jL2XMCpADBvSEiQUIBUBahKiQIesGOhdVNA1h_e64_YE6IrACllZR6zI1VDI0RTH7PrLzi5gZ_vqVsnv4Q48TDxzymMLu35xX7GNLvkln6fYmgDjTwQd0TRB7dgy3-FpecTzn2KQ26Do0CvOQ7481YmTOvIvRt8WMdi7iPNfRb4nGK7-oW7qeWbf0xjnJDnQRzoKXvUuYHw2V09Yd_ev_t6dlFcfvrw8eztZeGVrJbCG7UrsURsRClkrZUWVVVptVOdrGTpm7KUTkOrDYA2WiuBla_Lum5qg8506oS92nzzPT9WpMWOgTwOg5swrmRlA7Ixqqwhoy__Qa_imvLvDpRSIE1VN5mSG-VTJErY2Xl7pRVgD6HZLTSbQ7O3odmD9Ys763U3Yvtn5HdKGVAbQFmavmP6u_s_tjc8IKQG</recordid><startdate>20240301</startdate><enddate>20240301</enddate><creator>Banerjee, Mainak</creator><creator>Kar, Anish</creator><creator>Ahamed, Jan</creator><creator>Bhattacharjee, Rana</creator><creator>Maitra, Dhritiman</creator><creator>Maisnam, Indira</creator><creator>Das, Tapas Chandra</creator><creator>Sahana, Pranab Kumar</creator><creator>Chowdhury, Subhankar</creator><creator>Mukhopadhyay, Satinath</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8033-5748</orcidid></search><sort><creationdate>20240301</creationdate><title>Renal Dysfunction in Primary Hyperparathyroidism is associated with nephrolithiasis, elevated serum calcium-phosphate product and parathormone levels</title><author>Banerjee, Mainak ; Kar, Anish ; Ahamed, Jan ; Bhattacharjee, Rana ; Maitra, Dhritiman ; Maisnam, Indira ; Das, Tapas Chandra ; Sahana, Pranab Kumar ; Chowdhury, Subhankar ; Mukhopadhyay, Satinath</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c326t-c73b4e4ee914128535166653b3f2624c9442a50d5700575531e6c8488987ea7f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Alkaline phosphatase</topic><topic>Calcium (blood)</topic><topic>Calcium phosphates</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Endocrinology</topic><topic>Glomerular filtration rate</topic><topic>Hemoglobin</topic><topic>Humanities and Social Sciences</topic><topic>Hyperparathyroidism</topic><topic>Internal Medicine</topic><topic>Kidney stones</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>multidisciplinary</topic><topic>Multiple regression analysis</topic><topic>Nephrolithiasis</topic><topic>Original Article</topic><topic>Parathyroid hormone</topic><topic>Phenotypes</topic><topic>Renal function</topic><topic>Renal insufficiency</topic><topic>Risk assessment</topic><topic>Risk factors</topic><topic>Science</topic><topic>Serum levels</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Banerjee, Mainak</creatorcontrib><creatorcontrib>Kar, Anish</creatorcontrib><creatorcontrib>Ahamed, Jan</creatorcontrib><creatorcontrib>Bhattacharjee, Rana</creatorcontrib><creatorcontrib>Maitra, Dhritiman</creatorcontrib><creatorcontrib>Maisnam, Indira</creatorcontrib><creatorcontrib>Das, Tapas Chandra</creatorcontrib><creatorcontrib>Sahana, Pranab Kumar</creatorcontrib><creatorcontrib>Chowdhury, Subhankar</creatorcontrib><creatorcontrib>Mukhopadhyay, Satinath</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Endocrine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Banerjee, Mainak</au><au>Kar, Anish</au><au>Ahamed, Jan</au><au>Bhattacharjee, Rana</au><au>Maitra, Dhritiman</au><au>Maisnam, Indira</au><au>Das, Tapas Chandra</au><au>Sahana, Pranab Kumar</au><au>Chowdhury, Subhankar</au><au>Mukhopadhyay, Satinath</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Renal Dysfunction in Primary Hyperparathyroidism is associated with nephrolithiasis, elevated serum calcium-phosphate product and parathormone levels</atitle><jtitle>Endocrine</jtitle><stitle>Endocrine</stitle><addtitle>Endocrine</addtitle><date>2024-03-01</date><risdate>2024</risdate><volume>83</volume><issue>3</issue><spage>757</spage><epage>762</epage><pages>757-762</pages><issn>1559-0100</issn><issn>1355-008X</issn><eissn>1559-0100</eissn><abstract><![CDATA[Purpose
Baseline renal dysfunction predicts mortality in primary hyperparathyroidism (PHPT). However, it remains controversial whether renal insufficiency in PHPT is due to disease severity alone or other risk factors. This study aimed to explore the association of clinico-biochemical variables with renal dysfunction [estimated glomerular filtration rate (eGFR) < 60 ml/min/m
2
] in PHPT.
Methods
A total of 112 patients of PHPT were selected and divided into following subgroups: renal dysfunction (n = 28) and normal renal function (n = 84). Demographic characteristics, traditional risk factors, phenotypes of PHPT based on target organ involvement, and biochemical parameters were compared between these subgroups.
Results
Patient subgroups of PHPT with and without renal dysfunction had similar age, frequency of diabetes, and hypertension. Renal dysfunction was more prevalent in males (p < 0.05). Compared to normal renal function subgroup, individuals with renal dysfunction had higher serum levels of calcium, phosphate, alkaline phosphatase, intact parathormone (all p < 0.05), while having lower hemoglobin levels (p < 0.05) and higher nephrolithiasis rates (p < 0.05). Multiple regression analysis revealed that nephrolithiasis, serum calcium-phosphorous product (CaxP), parathormone levels were positively associated with baseline renal dysfunction (all p < 0.01). A baseline PTH > 456 pg/mL and CaxP > 30.0 mg
2
/dl
2
could discriminate renal dysfunction from normal renal function with sensitivity and specificity of 75% and 74.5% and 92.6% and 74.4%, respectively.
Conclusion
Renal dysfunction was associated with presence of nephrolithiasis, elevated serum CaxP and PTH levels in our cohort with predominantly symptomatic PHPT, indicating an association with the underlying disease itself. Serum CaxP may additionally be appraised during risk assessment in PHPT.]]></abstract><cop>New York</cop><pub>Springer US</pub><pmid>38091198</pmid><doi>10.1007/s12020-023-03631-0</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0001-8033-5748</orcidid></addata></record> |
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| subjects | Alkaline phosphatase Calcium (blood) Calcium phosphates Diabetes Diabetes mellitus Endocrinology Glomerular filtration rate Hemoglobin Humanities and Social Sciences Hyperparathyroidism Internal Medicine Kidney stones Medicine Medicine & Public Health multidisciplinary Multiple regression analysis Nephrolithiasis Original Article Parathyroid hormone Phenotypes Renal function Renal insufficiency Risk assessment Risk factors Science Serum levels |
| title | Renal Dysfunction in Primary Hyperparathyroidism is associated with nephrolithiasis, elevated serum calcium-phosphate product and parathormone levels |
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