Meningeal carcinomatosis with decreased visual acuity: a case report

Meningeal carcinomatosis is a condition in which cancer cells diffusely metastasize to the cerebral pia mater in the cerebrospinal membrane or cerebrospinal cavity. It causes a wide array of symptoms according to the site of metastasis. The prognosis is poor, especially in metastasis from solid tumo...

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Bibliographic Details
Published in:Clinical journal of gastroenterology 2024-04, Vol.17 (2), p.211-215
Main Authors: Kuramochi, Mizuki, Kaji, Ryosuke, Sumi, Ryutaro, Ikura, Akihiko, Takajo, Takeshi, Yamaguchi, Akihiro, Nozaki, Yumi, Hosoda, Yasuo
Format: Article
Language:English
Subjects:
Abdominal Surgery
Adenocarcinoma - complications
Aged
Case Report
Colorectal Surgery
Early Detection of Cancer
Gastroenterology
Hepatology
Humans
Male
Medicine
Medicine & Public Health
Meningeal Carcinomatosis - complications
Meningeal Carcinomatosis - diagnosis
Meningeal Carcinomatosis - drug therapy
Stomach Neoplasms - pathology
Surgical Oncology
Visual Acuity
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Summary:Meningeal carcinomatosis is a condition in which cancer cells diffusely metastasize to the cerebral pia mater in the cerebrospinal membrane or cerebrospinal cavity. It causes a wide array of symptoms according to the site of metastasis. The prognosis is poor, especially in metastasis from solid tumors. This study reports a case of meningeal carcinomatosis caused by advanced gastric cancer, manifested by headache and vision loss. The patient was a 69-year-old man who underwent head computed tomography (CT) and magnetic resonance imaging (MRI) for persistent headaches. No abnormal findings were found; however, his vision declined, convulsions occurred, and cerebrospinal fluid (CSF) cytology showed poorly differentiated adenocarcinoma. Therefore, meningeal carcinomatosis was diagnosed. The patient died after receiving FOLFOX therapy to relieve symptoms and prolong his life. An autopsy showed no invasion of the optic nerve or surrounding tissues. As the frequency of complications of meningeal carcinomatosis in solid cancers is rare, it is crucial to actively suspect and make an early diagnosis.
ISSN:1865-7257
1865-7265
DOI:10.1007/s12328-023-01896-6