Generation of Membrane Potential by Cytochrome bd

An overview of current notions on the mechanism of generation of a transmembrane electric potential difference (Δψ) during the catalytic cycle of a bd -type triheme terminal quinol oxidase is presented in this work. It is suggested that the main contribution to Δψ formation is made by the movement o...

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Bibliographic Details
Published in:Biochemistry (Moscow) 2023-10, Vol.88 (10), p.1504-1512
Main Author: Borisov, Vitaliy B.
Format: Article
Language:English
Subjects:
Analysis
Binding sites
Biochemistry
Biomedical and Life Sciences
Biomedicine
Bioorganic Chemistry
Cytochrome
Cytochrome b Group - metabolism
Cytochrome bd
Cytochrome c
Cytochromes - metabolism
Cytoplasm
E coli
Electric potential
Electron Transport Chain Complex Proteins - metabolism
Enzymes
Escherichia coli Proteins - metabolism
Life Sciences
Ligands
Membrane potential
Membrane Potentials
Membrane proteins
Membranes
Microbiology
Oxidation-Reduction
Proteins
Quinol oxidase
Review
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Summary:An overview of current notions on the mechanism of generation of a transmembrane electric potential difference (Δψ) during the catalytic cycle of a bd -type triheme terminal quinol oxidase is presented in this work. It is suggested that the main contribution to Δψ formation is made by the movement of H + across the membrane along the intra-protein hydrophilic proton-conducting pathway from the cytoplasm to the active site for oxygen reduction of this bacterial enzyme.
ISSN:0006-2979
1608-3040
DOI:10.1134/S0006297923100073