Stable isotope-assisted mass spectrometry reveals in vivo distribution, metabolism, and excretion of tire rubber-derived 6PPD-quinone in mice

6PPD-quinone (6PPD-Q) has been identified as a ubiquitous contaminant in the surrounding locality, including air particles, roadside soils, dust, and water. Recently, the prevalence of 6PPD-Q in human urine has accentuated the urgency for investigating its biological fate. To address this, we conduc...

Full description

Saved in:
Bibliographic Details
Published in:The Science of the total environment 2024-02, Vol.912, p.169291-169291, Article 169291
Main Authors: Zhang, Jing, Cao, Guodong, Wang, Wei, Qiao, Han, Chen, Yi, Wang, Xiaoxiao, Wang, Fuyue, Liu, Wenlan, Cai, Zongwei
Format: Article
Language:English
Subjects:
6PPD-quinone
Emerging contaminant
High-resolution mass spectrometry
Isotope labeling
Toxicokinetics
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:6PPD-quinone (6PPD-Q) has been identified as a ubiquitous contaminant in the surrounding locality, including air particles, roadside soils, dust, and water. Recently, the prevalence of 6PPD-Q in human urine has accentuated the urgency for investigating its biological fate. To address this, we conducted a stable isotope-assisted high-resolution mass spectrometry (HRMS) assay to unveil the distribution, metabolism, excretion, and toxicokinetic properties of this contaminant in a mouse model. Mice were fed with a single dose of deuterated 6PPD-Q-d5 at human-relevant exposure levels. Results indicated that 6PPD-Q was quickly assimilated and distributed into bloodstream and main organs of mice, with the concentrations reaching peaks under 1 h following administration. Notably, 6PPD-Q was primarily distributed in the adipose tissue, marked by a significant Cmax (p 
ISSN:0048-9697
1879-1026
DOI:10.1016/j.scitotenv.2023.169291