Natural orifice specimen extraction surgery versus small-incision assisted laparoscopic radical right hemicolectomy

Conventional laparoscopic-assisted right hemicolectomy requires a small abdominal incision to extract the specimen, which becomes an important source of postoperative complications and impairs perioperative experience. Transvaginal natural orifice specimen extraction surgery (NOSES VIIIA) avoids thi...

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Bibliographic Details
Published in:Future oncology (London, England) England), 2023-12, Vol.19 (40), p.2641-2650
Main Authors: Yu, Mengqin, Cai, Zhenghao, Zhou, Haitao, Fingerhut, Abraham, He, Zirui, Xue, Pei, Song, Haiqin, Yang, Xiao, Cheng, Xi, Zhang, Sen, Xu, Ximo, Zhong, Hao, Abuduaini, Naijipu, Liu, Jingyi, Wang, Xishan, Feng, Bo
Format: Article
Language:English
Subjects:
Adenocarcinoma - surgery
Clinical Trials, Phase III as Topic
Colectomy - adverse effects
Colonic Neoplasms - surgery
cosmetic outcomes
disease-free survival
Female
Humans
Laparoscopy - adverse effects
Laparoscopy - methods
Multicenter Studies as Topic
Natural Orifice Endoscopic Surgery - adverse effects
Natural Orifice Endoscopic Surgery - methods
natural orifice specimen extraction surgery (trans vaginal)
postoperative quality of life
randomized controlled trial
Randomized Controlled Trials as Topic
right colon cancer
right hemicolectomy
Treatment Outcome
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Summary:Conventional laparoscopic-assisted right hemicolectomy requires a small abdominal incision to extract the specimen, which becomes an important source of postoperative complications and impairs perioperative experience. Transvaginal natural orifice specimen extraction surgery (NOSES VIIIA) avoids this small incision by extracting the specimen through the vagina. Here we describe the design of a multicenter, open-label, parallel, noninferior, phase III randomized controlled trial (NCT 05495048). The aim of this study is to confirm that the NOSES VIIIA procedure is not inferior to small-incision assisted right hemicolectomy in long-term oncological efficacy. A total of 352 female patients with right colon adenocarcinoma/high-grade intraepithelial neoplasia will be randomly assigned to the NOSES VIIIA arm and the small-incision arm in a 1:1 ratio. The primary end point of this trial is 3 year disease-free survival. ( )
ISSN:1479-6694
1744-8301
DOI:10.2217/fon-2023-0769