Loading…
Vitreomacular interface abnormalities in type 2 macular telangiectasia (MacTel)
Purpose To describe the different types of vitreomacular interface abnormalities (VMIA) seen on optical coherence tomography (OCT) in type 2 macular telangiectasia (MacTel) and explain the possible reasons for its development. Methods In this retrospective cross-sectional study, type 2 MacTel eyes w...
Saved in:
| Published in: | Graefe's archive for clinical and experimental ophthalmology 2024-05, Vol.262 (5), p.1455-1463 |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | |
|---|---|
| cites | cdi_FETCH-LOGICAL-c326t-10aa007798aa8dd6e9a6f9530cfdee54c3bcd25de77f0ab83db181c6fbfcd1273 |
| container_end_page | 1463 |
| container_issue | 5 |
| container_start_page | 1455 |
| container_title | Graefe's archive for clinical and experimental ophthalmology |
| container_volume | 262 |
| creator | Venkatesh, Ramesh Mangla, Rubble Handa, Ashit Chitturi, Sai Prashanti Parmar, Yash Sangoram, Rohini Yadav, Naresh Kumar Chhablani, Jay |
| description | Purpose
To describe the different types of vitreomacular interface abnormalities (VMIA) seen on optical coherence tomography (OCT) in type 2 macular telangiectasia (MacTel) and explain the possible reasons for its development.
Methods
In this retrospective cross-sectional study, type 2 MacTel eyes with macular volumetric OCT imaging protocol were included to identify different types of VMIA such as abnormal PVD, vitreomacular traction (VMT), ERM, and lamellar and full-thickness macular hole. The VMIA findings were then correlated with different MacTel disease stages and visual acuity.
Results
One thousand forty-three OCTs of 332 type 2 MacTel eyes from 169 patients at different visits were examined. VMIA was detected in 709 (68%) of those OCT scans in 216 (65%) eyes. There were 273 (39%), 31 (4%), 89 (13%), 7 (1%), and 381 (54%) OCT scans with vitreomacular adhesion, VMT, ERM, and inner and outer lamellar macular holes discovered respectively. VMIA eyes had a high frequency of abnormal PVD (
p
= 0.001) and retinal pigment clumps (RPCs) [
p
= 0.032]. Eyes with abnormal PVD (
p
= 0.034) and RPC (
p
= 0.000) had a higher rate of ERM development. RPC was linked to an increased risk of developing ERM (odd ratio 2.472; 95% CI 1.488–4.052). RPC and ERM contributed significantly to poor visual acuity (0.661 ± 0.416, 20/92).
Conclusion
OCT reveals a high frequency of VMIA in advanced type 2 MacTel eyes. RPC could be responsible for the development of anomalous PVD, as well as subsequent VMIAs and ERM. Additional work is required to examine the long-term changes and surgical outcomes of these eyes. |
| doi_str_mv | 10.1007/s00417-023-06330-8 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2903324691</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3041673411</sourcerecordid><originalsourceid>FETCH-LOGICAL-c326t-10aa007798aa8dd6e9a6f9530cfdee54c3bcd25de77f0ab83db181c6fbfcd1273</originalsourceid><addsrcrecordid>eNp9kE1P3DAQhq2qqCzb_oEeUKRetofA2JPEzrFataUSiAsgbtbEmaCgfGzt5LD_Hi-7W6QeOFkaP_POzCPEVwkXEkBfBoBM6hQUplAgQmo-iIXMME81qMePYgFaydSgejwVZyE8Q-Qxl5_EKRoJpgS9ELcP7eR57MnNHfmkHSb2DTlOqBpG31PXTi2HWE-m7YYTlRzJiTsanlp2E4WWktUNuTvuvn8WJw11gb8c3qW4__Xzbn2VXt_-_rP-cZ06VMWUSiCKJ-jSEJm6LrikoilzBNfUzHnmsHK1ymvWugGqDNaVNNIVTdW4WiqNS7Ha5278-HfmMNm-DY67uBSPc7CqBESVFaWM6Lf_0Odx9kPczmIUWGjM5I5Se8r5MQTPjd34tie_tRLsTrfd67ZRt33VbU1sOj9Ez1XP9b-Wo98I4B4I8Wt4Yv82-53YF8Fzivo</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3041673411</pqid></control><display><type>article</type><title>Vitreomacular interface abnormalities in type 2 macular telangiectasia (MacTel)</title><source>Springer Nature</source><creator>Venkatesh, Ramesh ; Mangla, Rubble ; Handa, Ashit ; Chitturi, Sai Prashanti ; Parmar, Yash ; Sangoram, Rohini ; Yadav, Naresh Kumar ; Chhablani, Jay</creator><creatorcontrib>Venkatesh, Ramesh ; Mangla, Rubble ; Handa, Ashit ; Chitturi, Sai Prashanti ; Parmar, Yash ; Sangoram, Rohini ; Yadav, Naresh Kumar ; Chhablani, Jay</creatorcontrib><description>Purpose
To describe the different types of vitreomacular interface abnormalities (VMIA) seen on optical coherence tomography (OCT) in type 2 macular telangiectasia (MacTel) and explain the possible reasons for its development.
Methods
In this retrospective cross-sectional study, type 2 MacTel eyes with macular volumetric OCT imaging protocol were included to identify different types of VMIA such as abnormal PVD, vitreomacular traction (VMT), ERM, and lamellar and full-thickness macular hole. The VMIA findings were then correlated with different MacTel disease stages and visual acuity.
Results
One thousand forty-three OCTs of 332 type 2 MacTel eyes from 169 patients at different visits were examined. VMIA was detected in 709 (68%) of those OCT scans in 216 (65%) eyes. There were 273 (39%), 31 (4%), 89 (13%), 7 (1%), and 381 (54%) OCT scans with vitreomacular adhesion, VMT, ERM, and inner and outer lamellar macular holes discovered respectively. VMIA eyes had a high frequency of abnormal PVD (
p
= 0.001) and retinal pigment clumps (RPCs) [
p
= 0.032]. Eyes with abnormal PVD (
p
= 0.034) and RPC (
p
= 0.000) had a higher rate of ERM development. RPC was linked to an increased risk of developing ERM (odd ratio 2.472; 95% CI 1.488–4.052). RPC and ERM contributed significantly to poor visual acuity (0.661 ± 0.416, 20/92).
Conclusion
OCT reveals a high frequency of VMIA in advanced type 2 MacTel eyes. RPC could be responsible for the development of anomalous PVD, as well as subsequent VMIAs and ERM. Additional work is required to examine the long-term changes and surgical outcomes of these eyes.</description><identifier>ISSN: 0721-832X</identifier><identifier>EISSN: 1435-702X</identifier><identifier>DOI: 10.1007/s00417-023-06330-8</identifier><identifier>PMID: 38108907</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Acuity ; Cross-Sectional Studies ; Diabetic Retinopathy ; Eye ; Humans ; Macula Lutea ; Medicine ; Medicine & Public Health ; Ophthalmology ; Retinal Diseases - diagnosis ; Retinal Diseases - etiology ; Retinal Disorders ; Retinal Perforations - diagnosis ; Retinal Perforations - etiology ; Retrospective Studies ; Telangiectasis ; Tomography, Optical Coherence - methods ; Vision Disorders ; Visual acuity</subject><ispartof>Graefe's archive for clinical and experimental ophthalmology, 2024-05, Vol.262 (5), p.1455-1463</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c326t-10aa007798aa8dd6e9a6f9530cfdee54c3bcd25de77f0ab83db181c6fbfcd1273</cites><orcidid>0000-0002-4479-9390</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38108907$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Venkatesh, Ramesh</creatorcontrib><creatorcontrib>Mangla, Rubble</creatorcontrib><creatorcontrib>Handa, Ashit</creatorcontrib><creatorcontrib>Chitturi, Sai Prashanti</creatorcontrib><creatorcontrib>Parmar, Yash</creatorcontrib><creatorcontrib>Sangoram, Rohini</creatorcontrib><creatorcontrib>Yadav, Naresh Kumar</creatorcontrib><creatorcontrib>Chhablani, Jay</creatorcontrib><title>Vitreomacular interface abnormalities in type 2 macular telangiectasia (MacTel)</title><title>Graefe's archive for clinical and experimental ophthalmology</title><addtitle>Graefes Arch Clin Exp Ophthalmol</addtitle><addtitle>Graefes Arch Clin Exp Ophthalmol</addtitle><description>Purpose
To describe the different types of vitreomacular interface abnormalities (VMIA) seen on optical coherence tomography (OCT) in type 2 macular telangiectasia (MacTel) and explain the possible reasons for its development.
Methods
In this retrospective cross-sectional study, type 2 MacTel eyes with macular volumetric OCT imaging protocol were included to identify different types of VMIA such as abnormal PVD, vitreomacular traction (VMT), ERM, and lamellar and full-thickness macular hole. The VMIA findings were then correlated with different MacTel disease stages and visual acuity.
Results
One thousand forty-three OCTs of 332 type 2 MacTel eyes from 169 patients at different visits were examined. VMIA was detected in 709 (68%) of those OCT scans in 216 (65%) eyes. There were 273 (39%), 31 (4%), 89 (13%), 7 (1%), and 381 (54%) OCT scans with vitreomacular adhesion, VMT, ERM, and inner and outer lamellar macular holes discovered respectively. VMIA eyes had a high frequency of abnormal PVD (
p
= 0.001) and retinal pigment clumps (RPCs) [
p
= 0.032]. Eyes with abnormal PVD (
p
= 0.034) and RPC (
p
= 0.000) had a higher rate of ERM development. RPC was linked to an increased risk of developing ERM (odd ratio 2.472; 95% CI 1.488–4.052). RPC and ERM contributed significantly to poor visual acuity (0.661 ± 0.416, 20/92).
Conclusion
OCT reveals a high frequency of VMIA in advanced type 2 MacTel eyes. RPC could be responsible for the development of anomalous PVD, as well as subsequent VMIAs and ERM. Additional work is required to examine the long-term changes and surgical outcomes of these eyes.</description><subject>Acuity</subject><subject>Cross-Sectional Studies</subject><subject>Diabetic Retinopathy</subject><subject>Eye</subject><subject>Humans</subject><subject>Macula Lutea</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Ophthalmology</subject><subject>Retinal Diseases - diagnosis</subject><subject>Retinal Diseases - etiology</subject><subject>Retinal Disorders</subject><subject>Retinal Perforations - diagnosis</subject><subject>Retinal Perforations - etiology</subject><subject>Retrospective Studies</subject><subject>Telangiectasis</subject><subject>Tomography, Optical Coherence - methods</subject><subject>Vision Disorders</subject><subject>Visual acuity</subject><issn>0721-832X</issn><issn>1435-702X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kE1P3DAQhq2qqCzb_oEeUKRetofA2JPEzrFataUSiAsgbtbEmaCgfGzt5LD_Hi-7W6QeOFkaP_POzCPEVwkXEkBfBoBM6hQUplAgQmo-iIXMME81qMePYgFaydSgejwVZyE8Q-Qxl5_EKRoJpgS9ELcP7eR57MnNHfmkHSb2DTlOqBpG31PXTi2HWE-m7YYTlRzJiTsanlp2E4WWktUNuTvuvn8WJw11gb8c3qW4__Xzbn2VXt_-_rP-cZ06VMWUSiCKJ-jSEJm6LrikoilzBNfUzHnmsHK1ymvWugGqDNaVNNIVTdW4WiqNS7Ha5278-HfmMNm-DY67uBSPc7CqBESVFaWM6Lf_0Odx9kPczmIUWGjM5I5Se8r5MQTPjd34tie_tRLsTrfd67ZRt33VbU1sOj9Ez1XP9b-Wo98I4B4I8Wt4Yv82-53YF8Fzivo</recordid><startdate>20240501</startdate><enddate>20240501</enddate><creator>Venkatesh, Ramesh</creator><creator>Mangla, Rubble</creator><creator>Handa, Ashit</creator><creator>Chitturi, Sai Prashanti</creator><creator>Parmar, Yash</creator><creator>Sangoram, Rohini</creator><creator>Yadav, Naresh Kumar</creator><creator>Chhablani, Jay</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-4479-9390</orcidid></search><sort><creationdate>20240501</creationdate><title>Vitreomacular interface abnormalities in type 2 macular telangiectasia (MacTel)</title><author>Venkatesh, Ramesh ; Mangla, Rubble ; Handa, Ashit ; Chitturi, Sai Prashanti ; Parmar, Yash ; Sangoram, Rohini ; Yadav, Naresh Kumar ; Chhablani, Jay</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c326t-10aa007798aa8dd6e9a6f9530cfdee54c3bcd25de77f0ab83db181c6fbfcd1273</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Acuity</topic><topic>Cross-Sectional Studies</topic><topic>Diabetic Retinopathy</topic><topic>Eye</topic><topic>Humans</topic><topic>Macula Lutea</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Ophthalmology</topic><topic>Retinal Diseases - diagnosis</topic><topic>Retinal Diseases - etiology</topic><topic>Retinal Disorders</topic><topic>Retinal Perforations - diagnosis</topic><topic>Retinal Perforations - etiology</topic><topic>Retrospective Studies</topic><topic>Telangiectasis</topic><topic>Tomography, Optical Coherence - methods</topic><topic>Vision Disorders</topic><topic>Visual acuity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Venkatesh, Ramesh</creatorcontrib><creatorcontrib>Mangla, Rubble</creatorcontrib><creatorcontrib>Handa, Ashit</creatorcontrib><creatorcontrib>Chitturi, Sai Prashanti</creatorcontrib><creatorcontrib>Parmar, Yash</creatorcontrib><creatorcontrib>Sangoram, Rohini</creatorcontrib><creatorcontrib>Yadav, Naresh Kumar</creatorcontrib><creatorcontrib>Chhablani, Jay</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Graefe's archive for clinical and experimental ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Venkatesh, Ramesh</au><au>Mangla, Rubble</au><au>Handa, Ashit</au><au>Chitturi, Sai Prashanti</au><au>Parmar, Yash</au><au>Sangoram, Rohini</au><au>Yadav, Naresh Kumar</au><au>Chhablani, Jay</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vitreomacular interface abnormalities in type 2 macular telangiectasia (MacTel)</atitle><jtitle>Graefe's archive for clinical and experimental ophthalmology</jtitle><stitle>Graefes Arch Clin Exp Ophthalmol</stitle><addtitle>Graefes Arch Clin Exp Ophthalmol</addtitle><date>2024-05-01</date><risdate>2024</risdate><volume>262</volume><issue>5</issue><spage>1455</spage><epage>1463</epage><pages>1455-1463</pages><issn>0721-832X</issn><eissn>1435-702X</eissn><abstract>Purpose
To describe the different types of vitreomacular interface abnormalities (VMIA) seen on optical coherence tomography (OCT) in type 2 macular telangiectasia (MacTel) and explain the possible reasons for its development.
Methods
In this retrospective cross-sectional study, type 2 MacTel eyes with macular volumetric OCT imaging protocol were included to identify different types of VMIA such as abnormal PVD, vitreomacular traction (VMT), ERM, and lamellar and full-thickness macular hole. The VMIA findings were then correlated with different MacTel disease stages and visual acuity.
Results
One thousand forty-three OCTs of 332 type 2 MacTel eyes from 169 patients at different visits were examined. VMIA was detected in 709 (68%) of those OCT scans in 216 (65%) eyes. There were 273 (39%), 31 (4%), 89 (13%), 7 (1%), and 381 (54%) OCT scans with vitreomacular adhesion, VMT, ERM, and inner and outer lamellar macular holes discovered respectively. VMIA eyes had a high frequency of abnormal PVD (
p
= 0.001) and retinal pigment clumps (RPCs) [
p
= 0.032]. Eyes with abnormal PVD (
p
= 0.034) and RPC (
p
= 0.000) had a higher rate of ERM development. RPC was linked to an increased risk of developing ERM (odd ratio 2.472; 95% CI 1.488–4.052). RPC and ERM contributed significantly to poor visual acuity (0.661 ± 0.416, 20/92).
Conclusion
OCT reveals a high frequency of VMIA in advanced type 2 MacTel eyes. RPC could be responsible for the development of anomalous PVD, as well as subsequent VMIAs and ERM. Additional work is required to examine the long-term changes and surgical outcomes of these eyes.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>38108907</pmid><doi>10.1007/s00417-023-06330-8</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-4479-9390</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0721-832X |
| ispartof | Graefe's archive for clinical and experimental ophthalmology, 2024-05, Vol.262 (5), p.1455-1463 |
| issn | 0721-832X 1435-702X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2903324691 |
| source | Springer Nature |
| subjects | Acuity Cross-Sectional Studies Diabetic Retinopathy Eye Humans Macula Lutea Medicine Medicine & Public Health Ophthalmology Retinal Diseases - diagnosis Retinal Diseases - etiology Retinal Disorders Retinal Perforations - diagnosis Retinal Perforations - etiology Retrospective Studies Telangiectasis Tomography, Optical Coherence - methods Vision Disorders Visual acuity |
| title | Vitreomacular interface abnormalities in type 2 macular telangiectasia (MacTel) |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-23T21%3A33%3A19IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Vitreomacular%20interface%20abnormalities%20in%20type%202%20macular%20telangiectasia%20(MacTel)&rft.jtitle=Graefe's%20archive%20for%20clinical%20and%20experimental%20ophthalmology&rft.au=Venkatesh,%20Ramesh&rft.date=2024-05-01&rft.volume=262&rft.issue=5&rft.spage=1455&rft.epage=1463&rft.pages=1455-1463&rft.issn=0721-832X&rft.eissn=1435-702X&rft_id=info:doi/10.1007/s00417-023-06330-8&rft_dat=%3Cproquest_cross%3E3041673411%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c326t-10aa007798aa8dd6e9a6f9530cfdee54c3bcd25de77f0ab83db181c6fbfcd1273%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=3041673411&rft_id=info:pmid/38108907&rfr_iscdi=true |