Beyond Eosinophilic Esophagitis: Eosinophils in Gastrointestinal Disease—New Insights, “New” Diseases

Abstract Functional dyspepsia (FD) is a highly prevalent disorder. Upper endoscopy is normal, and according to the Rome IV criteria, there is no established pathology. Data accumulated over the last 15 years has challenged the notion FD is free of relevant pathology, and in particular, increased duo...

Full description

Saved in:
Bibliographic Details
Published in:Journal of the Canadian Association of Gastroenterology 2023-12, Vol.6 (6), p.199-211
Main Authors: Talley, Nicholas J, Burns, Grace L, Hoedt, Emily C, Duncanson, Kerith, Keely, Simon
Format: Article
Language:English
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Functional dyspepsia (FD) is a highly prevalent disorder. Upper endoscopy is normal, and according to the Rome IV criteria, there is no established pathology. Data accumulated over the last 15 years has challenged the notion FD is free of relevant pathology, and in particular, increased duodenal eosinophils have been observed. Intestinal eosinophils play important roles in microbial defence, immune regulation, tissue regeneration and remodelling, and maintaining tissue homeostasis and metabolism; degranulation of eosinophils releases toxic granule products (e.g., major basic protein, eosinophil-derived neurotoxin) which can damage nerves. Normal cut-offs for eosinophil infiltration into the duodenum histologically are less than five eosinophils per high power field (
ISSN:2515-2084
2515-2092
DOI:10.1093/jcag/gwad046